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Titolo:
A role for the cytoskeleton-associated protein palladin in neurite outgrowth
Autore:
Boukhelifa, M; Parast, MM; Valtschanoff, JG; LaMantia, AS; Meeker, RB; Otey, CA;
Indirizzi:
Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA Univ NCarolina Chapel Hill NC USA 27599 ysiol, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Cell Biol & Anat, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 Anat, Chapel Hill, NC 27599 USA Univ N Carolina, Dept Neurol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 eurol, Chapel Hill, NC 27599 USA
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2721 - 2729
SICI:
1059-1524(200109)12:9<2721:ARFTCP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH CONE GUIDANCE; RHO-FAMILY GTPASES; HIPPOCAMPAL-NEURONS; ACTIN POLYMERIZATION; DENDRITIC GROWTH; AXON OUTGROWTH; POLARITY; CULTURE; ESTABLISHMENT; ORGANIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Otey, CA Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 apel Hill, NC 27599 USA
Citazione:
M. Boukhelifa et al., "A role for the cytoskeleton-associated protein palladin in neurite outgrowth", MOL BIOL CE, 12(9), 2001, pp. 2721-2729

Abstract

The outgrowth of neurites is a critical step in neuronal maturation, and it is well established that the actin cytoskeleton is involved in this process. Investigators from our laboratory recently described a novel protein named palladin, which has been shown to play an essential role in organizing the actin cytoskeleton in cultured fibroblasts. We investigated the expression of palladin in the developing rat brain by Western blot and found that the E18 brain contained a unique variant of palladin that is significantly smaller (similar to 85 kDa) than the common form found in other developing tissues (90-92 kDa). Because the expression of a tissue-specific isoform suggests the possibility of a cell type-specific function, we investigated the localization and function of palladin in cultured cortical neurons. Palladin was found preferentially targeted to the developing axon but not the dendrites and was strongly localized to the axonal growth cone. When palladinexpression was attenuated by transfection with antisense constructs in both the B35 neuroblastoma cell line and in primary cortical neurons, a reduction in the expression of palladin resulted in a failure of neurite outgrowth. These results implicate palladin as a critical component of the developing nervous system, with an important role in axonal extension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:14:49