Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Insulin-mediated changes in leg blood flow are coupled to capillary density in skeletal muscle in healthy 70-year-old men
Autore:
Hedman, A; Andersson, PE; Reneland, R; Lithell, HO;
Indirizzi:
Uppsala Univ, Dept Publ Hlth & Caring Sci, Sect Geriatr, SE-75125 Uppsala,Sweden Uppsala Univ Uppsala Sweden SE-75125 ct Geriatr, SE-75125 Uppsala,Sweden
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 9, volume: 50, anno: 2001,
pagine: 1078 - 1082
SICI:
0026-0495(200109)50:9<1078:ICILBF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC-NERVE ACTIVITY; GLUCOSE-UPTAKE; FATTY-ACIDS; ELDERLY MEN; FIBER TYPE; VASODILATION; SENSITIVITY; EXERCISE; HUMANS; RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Hedman, A Uppsala Univ, Dept Publ Hlth & Caring Sci, Sect Geriatr, Kalsangsgrand 10 D,POB 609, SE-75125 Uppsala, Sweden Uppsala Univ Kalsangsgrand 10D,POB 609 Uppsala Sweden SE-75125
Citazione:
A. Hedman et al., "Insulin-mediated changes in leg blood flow are coupled to capillary density in skeletal muscle in healthy 70-year-old men", METABOLISM, 50(9), 2001, pp. 1078-1082

Abstract

The aim of this study was to investigate to what degree the capillarization in the skeletal muscle explains the leg blood flow (LBF) changes during hyperinsulinaemia. Fifteen normotensive men from a population-based cohort of 70-year-old men in Uppsala, Sweden, were investigated. Their metabolic status (oral glucose tolerance test and euglycemic, hyperinsulinaemic clamp test results), serum lipid profile, muscle fiber distribution (myosin adenosine triphosphatase staining), and capillary supply (amylase-periodic acid-Schiff method) was evaluated. Doppler ultrasound was used before and after the clamp test to detect insulin-induced changes in LBF. Physiologic hyperinsulinemia (serum insulin, 107 mU/L) caused a moderate increase in LBF (15% /- 11%; P =.07). Change in LBF was closely related to capillary density (r=.66; P <.01) independent of obesity, smoking and level of physical activity. An association was observed between LBF and serum free fatty acid (FFA)concentrations (r = -.57; P <.05). In multiple regression analysis, capillary density and serum FFA level together explained 71% of the variation in insulin-mediated LBF changes. Capillary rarefaction and elevated serum FFA values were associated with a vasoconstrictive effect of insulin. In conclusion, capillarization in skeletal muscle and serum FFA concentration seem to be determinants of endothelial function. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:59:30