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Titolo:
Exercise adds to metformin and acarbose efficacy in db/db mice
Autore:
Tang, TC; Reed, MJ;
Indirizzi:
Shaman Pharmaceut Inc, S San Francisco, CA USA Shaman Pharmaceut Inc S San Francisco CA USA nc, S San Francisco, CA USA
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 9, volume: 50, anno: 2001,
pagine: 1049 - 1053
SICI:
0026-0495(200109)50:9<1049:EATMAA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; CARBOHYDRATE-INDUCED HYPERTRIGLYCERIDEMIA; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Reed, MJ Tularik Inc, 2 Corp Dr, S San Francisco, CA 94080 USA Tularik Inc2 Corp Dr S San Francisco CA USA 94080 , CA 94080 USA
Citazione:
T.C. Tang e M.J. Reed, "Exercise adds to metformin and acarbose efficacy in db/db mice", METABOLISM, 50(9), 2001, pp. 1049-1053

Abstract

Physical exercise is frequently recommended for the treatment of type 2 diabetes, whether as primary therapy with diet modification or as an adjunct to drug therapy. We hypothesized that mild exercise would enhance the glucose-lowering effects of 2 oral antihyperglycemic drugs, metformin and acarbose, in an animal model of type 2 diabetes, Eight-week-old male C57BL/Ks (db/db) mice were sorted into control and exercise groups and dosed daily for 4 weeks with vehicle, metformin (150 mg/kg/d), or acarbose (40 mg/kg/d). Exercise consisted of swimming (initially 5 min/d and ultimately 1 h/d for the last 2 weeks). Exercise, metformin, and acarbose independently reduced serum glucose concentrations 15% to 25% compared with the respective controls(P < .0001), but the effect on glucose concentration of combining drug therapy with exercise was no greater than the sum of the individual effects. Exercise training independently increased muscle glycogen (30%; P < .05) andliver glycogen (250%; P < .05) levels and slightly reduced serum high-density lipoprotein cholesterol (-8%; P < .05), whereas drug treatment had no effect on these variables. In addition, exercise but not drug treatment prevented the approximately 30% decline in serum insulin concentrations that occurred in the control animals (P < .05). Twenty-four hours after the last drug or exercise treatment, oral glucose tolerance and hemoglobin Ale were not significantly different between groups. Treatment also did not greatly affect triglyceride, glycerol, or total cholesterol concentrations. In conclusion, exercise and drug therapy independently decreased serum glucose in db/db mice, and these effects did not appear to be synergistic. In addition,exercise training maintained serum insulin concentrations and increased tissue glycogen storage. These results suggest that exercise has the potential to add to the efficacy of oral antihyperglycemic drugs. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:26:48