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Titolo:
Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis
Autore:
Reddy, S; Andl, T; Bagasra, A; Lu, MM; Epstein, DJ; Morrisey, EE; Millar, SE;
Indirizzi:
Univ Penn, Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dermatol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Dev Biol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Med, Div Cardiol, Philadelphia, PA 19104 USA UnivPenn Philadelphia PA USA 19104 v Cardiol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 ept Genet, Philadelphia, PA 19104 USA
Titolo Testata:
MECHANISMS OF DEVELOPMENT
fascicolo: 1-2, volume: 107, anno: 2001,
pagine: 69 - 82
SICI:
0925-4773(200109)107:1-2<69:COWGEI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL-CELL CARCINOMAS; CONVERGENT EXTENSION MOVEMENTS; DROSOPHILA PATCHED PTCH; LABEL-RETAINING CELLS; BETA-CATENIN; SIGNALING PATHWAY; HUMAN HOMOLOG; TISSUE POLARITY; XENOPUS-LAEVIS; MOUSE DEVELOPMENT;
Keywords:
hair follicle; Wnt; Sonic hedgehog; mouse; skin; signaling; epidermis; dermis; dermal condensate; dermal papilla; outer root sheath; inner root sheath; gene expression; morphogenesis; basal cell carcinoma; placode; hair shaft; anagen; telogen; catagen; hair growth cycle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
96
Recensione:
Indirizzi per estratti:
Indirizzo: Millar, SE M8D Stellar Chance Labs, 422 Curie Blvd, Philadelphia, PA 19104USA M8D Stellar Chance Labs 422 Curie Blvd Philadelphia PA USA 19104
Citazione:
S. Reddy et al., "Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis", MECH DEVEL, 107(1-2), 2001, pp. 69-82

Abstract

Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type but not Sonic hedgehog (Shh)-null embryos, indicating that Wnt5a is a target of SHH in hair follicle morphogenesis. These results identify candidates for several key follicularsignals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:17:00