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Titolo:
Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers
Autore:
Marroquin, CE; Marino, G; Kuo, PC; Plotkin, JS; Rustgi, VK; Lu, AD; Edwards, E; Taranto, S; Johnson, LB;
Indirizzi:
Georgetown Univ, Med Ctr, Dept Surg, Div Transplant & Hepatobiliary Surg, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 ry Surg, Washington, DC 20007 USA United Network Organ Sharing, Richmond, VA USA United Network Organ Sharing Richmond VA USA n Sharing, Richmond, VA USA
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 9, volume: 7, anno: 2001,
pagine: 762 - 768
SICI:
1527-6465(200109)7:9<762:TOHCLI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DONOR POOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, LB Georgetown Univ, Med Ctr, Dept Surg, Div Transplant & Hepatobiliary Surg, 3800 Resevoir Rd NW, Washington, DC 20007 USA Georgetown Univ 3800 Resevoir Rd NW Washington DC USA 20007 SA
Citazione:
C.E. Marroquin et al., "Transplantation of hepatitis C-positive livers in hepatitis C-positive patients is equivalent to transplanting hepatitis C-negative livers", LIVER TRANS, 7(9), 2001, pp. 762-768

Abstract

A significant number of patients with end-stage liver disease secondary tohepatitis C die of disease-related complications. Liver transplantation offers the only effective alternative. Unfortunately, organ demand exceeds supply. Consequently, some transplant centers have used hepatitis C virus-positive (HCV+) donor livers for HCV+ recipients. This study reviews the clinical outcome of a large series of HCV+ recipients of HCV+ liver allografts and compares their course with that of HCV+ recipients of HCV-negative (HCV-) allografts. The United Network for Organ Sharing Scientific Registry was reviewed for the period from April 1, 1994, to June 30, 1997. All HCV+ transplant recipients were analyzed. Two groups were identified: a group of HCV recipients of HCV+ donor livers (n = 96), and a group of HCV+ recipients of HCV- donor livers (n = 2,827). A multivariate logistic regression model was used to determine the odds of graft failure and patient mortality, and unadjusted graft and patient survival were determined using the Kaplan-Meier method. There were no differences in demographic criteria between the groups. A greater percentage of patients with hepatocellular carcinoma received an HCV+ allograft (8.3% v 3.1%, P = .01). Patient survival showed a significant difference for the HCV+ group compared with the HCV- group (90% v 77%; P = .01). Blood type group A, group B, group O incompatibility was significant, with 4.2% incompatibility in the HCV+ group and only 1.3% in the HCV- group (P = .04). Donor hepatitis C status does not impact on graft or patient survival after liver transplantation for HCV+ recipients. Their survival was equivalent, if not better, compared with the control group. Using HCV+ donor livers for transplantation in HCV+ recipients safely and effectively expands the organ donor pool.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:05:14