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Titolo:
Vacuum-assisted resection of malignant tumors with and without subsequent radiofrequency ablation: Feasibility of complete tumor treatment tested in an animal model
Autore:
Boehm, T; Malich, A; Goldberg, SN; Reichenbach, JR; Hilger, I; Fleck, M; Kaiser, WA;
Indirizzi:
Univ Zurich Hosp, Inst Diagnost Radiol, Dept Med Radiol, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Jena, Inst Diagnost & Intervent Radiol, D-6900 Jena, Germany Univ Jena Jena Germany D-6900 t & Intervent Radiol, D-6900 Jena, Germany Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Radiol, Boston,MA USA Harvard Univ Boston MA USA Deaconess Med Ctr, Dept Radiol, Boston,MA USA
Titolo Testata:
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
fascicolo: 9, volume: 12, anno: 2001,
pagine: 1086 - 1093
SICI:
1051-0443(200109)12:9<1086:VROMTW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENIGN PROSTATIC HYPERPLASIA; MICROBUBBLE CONTRAST AGENT; STEREOTAXIC BREAST BIOPSY; CARCINOMA IN-SITU; PERCUTANEOUS REMOVAL; MAMMOGRAPHIC LESIONS; EARLY EXPERIENCE; CANCER; US; ELECTRODE;
Keywords:
animal model; neoplasms, therapy; radiofrequency (RF) ablation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Boehm, T Univ Zurich Hosp, Inst Diagnost Radiol, Dept Med Radiol, Ramistr 100, CH-8091 Zurich, Switzerland Univ Zurich Hosp Ramistr 100 Zurich Switzerland CH-8091 tzerland
Citazione:
T. Boehm et al., "Vacuum-assisted resection of malignant tumors with and without subsequent radiofrequency ablation: Feasibility of complete tumor treatment tested in an animal model", J VAS INT R, 12(9), 2001, pp. 1086-1093

Abstract

Purpose: To evaluate the feasibility of vacuum-assisted tumor excision with and without RF ablation for the minimally invasive treatment of small tumors. Materials and methods: Twenty VX2 tumors were implanted bilaterally into the spine muscle of 10 rabbits. Tumor excision was performed after tumor sizes reached 10 mm (12-27 d incubation) with use of a vacuum-assisted biopsy device. Three or four directed vacuum-assisted biopsies were performed in angle steps of 30 degrees. In 10 tumors, ultrasound (US)-guided radiofrequency (RF) ablation (8 min, 60 W) was subsequently performed with use of a cooled-tip electrode system. Follow-up US was performed at 3-4-day intervals for as long as 3 weeks after excision/RF ablation. Autopsy and histopathologic analysis were performed. Results: The duration of vacuum excision ranged from 12 to 45 minutes (25 min +/- 7). Histologically tumor-free margins in the outer round of the core biopsy specimens were found in only four of 20 cases (20%). Maximum lesion sizes during RF ablation ranged from 18 to 25 mm (20 mm +/- 2.6). Histologic examination of the excision specimens documented tumor-free margins in only three tumors (30%) among the excision-only group and only one (10%) among the combined excision/ablation group. Local recurrences occurred in eight of 10 cases (80%) after vacuum excision alone, whereas recurrence after combined excision and RF ablation occurred only in two of 10 cases (20%; P<.05). Conclusions: Local tumor resection with use of vacuum-assisted biopsy is feasible and promising as a minimally invasive therapy for the treatment of small focal breast neoplasms. Combined excision and RF ablation techniques may reduce the rate of local recurrence considerably.

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Documento generato il 06/04/20 alle ore 08:14:31