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Titolo:
Does early cystectomy improve the survival of patients with high risk superficial bladder tumors?
Autore:
Herr, HW; Sogani, PC;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Dept Urol, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
JOURNAL OF UROLOGY
fascicolo: 4, volume: 166, anno: 2001,
pagine: 1296 - 1299
SICI:
0022-5347(200110)166:4<1296:DECITS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACILLUS-CALMETTE-GUERIN; RADICAL CYSTECTOMY; CANCER; PROGRESSION; THERAPY; TIS; TA;
Keywords:
bladder; bladder neoplasms; cystectomy; Mycobacterium bovis; risk;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Herr, HW Mem Sloan Kettering Canc Ctr, Dept Urol, 1275 York Ave, New York,NY 10021USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
H.W. Herr e P.C. Sogani, "Does early cystectomy improve the survival of patients with high risk superficial bladder tumors?", J UROL, 166(4), 2001, pp. 1296-1299

Abstract

Purpose: We compared survival after early versus delayed cystectomy in patients with high risk superficial bladder tumors. Materials and Methods: Of 307 patients with high risk superficial bladder tumors who were treated initially with transurethral resection and bacillusCalmette-Guerin (BCG) therapy 90 (29%) underwent cystectomy for recurrent tumor during a followup of 15 to 20 years. Disease specific survival distribution of these 90 patients was determined relative to the indications for and time of cystectomy. Results: Of the 90 patients who underwent cystectomy 44 (49%) survived a median of 96 months. Of 35 patients with recurrent superficial bladder tumors 92% and 56% survived who underwent cystectomy less than 2 years after initial BCG therapy and after 2 years of followup, respectively. Of 55 patients with recurrent muscle invasive bladder disease 41% and 18% survived when cystectomy was performed within and after 2 years, respectively. Multivariate analysis showed that survival was improved in patients who underwent earlier rather than delayed cystectomy for nonmuscle invasive tumor relapse. Conclusions: Earlier cystectomy improves the long-term survival of patients with high risk superficial bladder tumors in whom BCG therapy fails.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:30:29