Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients
Autore:
Kozora, E; Laudenslager, M; Lemieux, A; West, SG;
Indirizzi:
Natl Jewish Med & Res Ctr, Denver, CO 80206 USA Natl Jewish Med & Res CtrDenver CO USA 80206 s Ctr, Denver, CO 80206 USA Univ Colorado, Sch Med, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 Colorado, Sch Med, Denver, CO 80262 USA
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 6, volume: 7, anno: 2001,
pagine: 745 - 754
SICI:
1355-6177(200109)7:6<745:IAHMPN>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM DEHYDROEPIANDROSTERONE SULFATE; POSTTRAUMATIC-STRESS-DISORDER; COGNITIVE IMPAIRMENT; PSYCHIATRIC-DISORDER; HIPPOCAMPAL VOLUME; ALZHEIMERS-DISEASE; ELEVATED LEVELS; SEX-DIFFERENCES; MICE; DEPRESSION;
Keywords:
lupus; neuropsychological; IL-6; DHEA-S; cortisol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Kozora, E Natl Jewish Med & Res Ctr, 1400 Jackson St, Denver, CO 80206 USANatl Jewish Med & Res Ctr 1400 Jackson St Denver CO USA 80206 SA
Citazione:
E. Kozora et al., "Inflammatory and hormonal measures predict neuropsychological functioning in systemic lupus erythematosus and rheumatoid arthritis patients", J INT NEURO, 7(6), 2001, pp. 745-754

Abstract

Abnormalities of inflammatory and hormonal measures are common in SLE patients. Although cognitive dysfunction has been documented in SLE patients, the biological mechanism of these deficits has not been clarified. The goal of this study was to explore the relationship between inflammatory and hormonal activity and measures of learning, fluency, and attention in systemic lupus erythematosus patients without neuropsychiatric symptoms (non-CNS-SLE), patients with rheumatoid arthritis (RA), and healthy controls (HC). Fifteen non-CNS-SLE patients, 15 RA patients and 15 TIC participants similar inage, education, and gender (female) were compared on tests of cognition, depression, and plasma levels of interleukin-6 (IL-6), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S) and cortisol. Non-CNS-SLEpatients demonstrated lower learning and poorer attention. Furthermore, non-CNS-SLE and RA patients had significantly lower levels of DHEA and DHEA-Sthan HC participants. Hierarchical regression analysis demonstrates that DHEA-S and IL-6 accounts for a unique portion of the variance in subject performance on measures of learning and attention after controlling for depression and corticosteroid treatment. This data highlights the value of hierarchical analyses with covariates, and provides evidence in humans of a relationship between peripheral cytokine levels and cognitive function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:10:26