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Titolo:
Attention problems in adolescents with congenital hypothyroidism: A multicomponential analysis
Autore:
Rovet, JF; Hepworth, S;
Indirizzi:
Hosp Sick Children, Brain & Behav Program, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Univ Toronto, Dept Pediat, Toronto, ON, Canada Univ Toronto Toronto ON Canada Toronto, Dept Pediat, Toronto, ON, Canada Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada
Titolo Testata:
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
fascicolo: 6, volume: 7, anno: 2001,
pagine: 734 - 744
SICI:
1355-6177(200109)7:6<734:APIAWC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; TRAUMATIC BRAIN INJURY; THYROID-HORMONE; NEUROLOGICAL DEVELOPMENT; CURRENT PERSPECTIVES; THYROXINE THERAPY; CHILDREN; MOTOR; EXPRESSION; SYSTEMS;
Keywords:
attention; congenital hypothyroidism; thyroid hormone; focus; concentrate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Rovet, JF Hosp Sick Children, Brain & Behav Program, 555 Univ Ave, Toronto, ON M5G 1X8, Canada Hosp Sick Children 555 Univ Ave Toronto ON Canada M5G 1X8 Canada
Citazione:
J.F. Rovet e S. Hepworth, "Attention problems in adolescents with congenital hypothyroidism: A multicomponential analysis", J INT NEURO, 7(6), 2001, pp. 734-744

Abstract

Even though early treatment of congenital hypothyroidism (CH) with newbornscreening prevents the mental retardation previously seen in cretinism, affected children still exhibit subtle persisting neurocognitive deficits. One of their commonest problems is poor attention, which reflects both early disease severity and later (high) circulating thyroid hormone levels. Whileattention is currently regarded as multicomponential in nature, with different processing components supported by different brain regions, the specific components of attention affected by CH have not been identified. In light of animal evidence showing that neonatal thyroid hormone deficiencies impede the neurodevelopment of structures important for selective aspects of attention, we proposed a multicomponential approach to study attention in children with CH. This was accomplished via retrospective analysis of existing data on adolescents with CH whose attention was previously evaluated using multiple tests. Results showed significantly poorer overall attention in CH than controls with differences occurring mainly on focus and inhibit indices. However, performance on various indices was associated with differentdisease parameters. Poor encode and focus were correlated with more severehypothyroidism and a longer period of thyroid hormone insufficiency and poor select and shift with higher thyroid hormone levels at testing. These results signify that thyroid hormone is important for the development and later regulation of brain structures supporting distinct aspects of attention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:31:42