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Titolo:
Pharmacokinetic and local tissue disposition of [C-14]sodium diclofenac following iontophoresis and systemic administration in rabbits
Autore:
Hui, XY; Anigbogu, A; Singh, P; Xiong, G; Poblete, N; Liu, PC; Maibach, HI;
Indirizzi:
Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA Novartis Pharmaceut Corp, Pharmaceut Dev, E Hanover, NJ 07936 USA NovartisPharmaceut Corp E Hanover NJ USA 07936 , E Hanover, NJ 07936 USA
Titolo Testata:
JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 9, volume: 90, anno: 2001,
pagine: 1269 - 1276
SICI:
0022-3549(200109)90:9<1269:PALTDO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
WATER-LOSS MEASUREMENTS; CUTANEOUS BLOOD-FLOW; TRANSDERMAL IONTOPHORESIS; TOPICAL APPLICATION; HUMAN SKIN; IN-VIVO; DELIVERY; ACID; RAT; TRANSPORT;
Keywords:
iontophoresis; local tissue disposition; sodium diclofenac; rabbit;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Hui, XY Univ Calif San Francisco, Dept Dermatol, Surge 110,Box 0989, San Francisco, CA 94143 USA Univ Calif San Francisco Surge 110,Box 0989 San Francisco CA USA 94143
Citazione:
X.Y. Hui et al., "Pharmacokinetic and local tissue disposition of [C-14]sodium diclofenac following iontophoresis and systemic administration in rabbits", J PHARM SCI, 90(9), 2001, pp. 1269-1276

Abstract

The systemic pharmacokinetics and local drug distribution of sodium diclofenac in skin and underlying tissues was studied. Iontophoresis facilitated local and systemic delivery of diclofenac sodium compared with passive diffusion. The maximum plasma concentration of sodium diclofenac was achieved within 1 h of iontophoresis, and the delivery was proportional to applied current density (371 +/- 141 and 132 +/- 62 mug/L at 0.5 and 0.2 mA/cm(2) respectively). The in vivo delivery efficiency for diclofenac in rabbit was 0.15 mg/mA.h. The concentrations of sodium diclofenac in the skin, subcutanoeus tissue, and muscle beneath the drug application site (cathode) were significantly greater than plasma concentrations and concentrations of drug in similar tissues at the untreated sites. The results thus suggest that the cutaneous microvasculature is not always a perfect "sink" and that transdermal iontophoresis facilitated the direct penetration of diclofenac sodium todeeper tissues. No skin irritation was observed up to 0.5 mA/cm(2) currentdensity and 7 mg/mL sodium diclofenac concentration. (C) 2001 Wiley-Liss, Inc. and the American Pharmaceutical Association.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 17:48:08