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Titolo:
The changes of vitreous pH values in an acute glaucoma rabbit model
Autore:
Lu, DW; Chang, CJ; Wu, JN;
Indirizzi:
Triserv Gen Hosp, Dept Ophthalmol, Sect 2, Natl Def Med Ctr, Taipei 114, Taiwan Triserv Gen Hosp Taipei Taiwan 114 Natl Def Med Ctr, Taipei 114, Taiwan
Titolo Testata:
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
fascicolo: 4, volume: 17, anno: 2001,
pagine: 343 - 350
SICI:
1080-7683(200108)17:4<343:TCOVPV>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGLE-CLOSURE GLAUCOMA; INTRAOCULAR-PRESSURE; AUTO-REGULATION; CAT RETINA; OXYGEN; PHOTORECEPTORS; ACIDOSIS; HYPOXIA; DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Lu, DW Triserv Gen Hosp, Dept Ophthalmol, Sect 2, Natl Def Med Ctr, 325,Cheng Kong Rd, Taipei 114, Taiwan Triserv Gen Hosp 325,Cheng Kong Rd Taipei Taiwan 114 i 114, Taiwan
Citazione:
D.W. Lu et al., "The changes of vitreous pH values in an acute glaucoma rabbit model", J OCUL PH T, 17(4), 2001, pp. 343-350

Abstract

The changes of vitreous pH values under acute glaucoma status have never been reported. In this study, we measured the changes of vitreous pH values in an acute glaucoma rabbit model. Under ketamine and xylazine anesthesia, the anterior chamber of the right eye of New Zealand white rabbits was cannulated and connected to a polygraph for continuous intraocular pressure (IOP) monitoring and a mini-pump for persistent injection of viscoelastic substance, Healon GV. The measurement of vitreous pH was done by inserting a pHprobe via a third opening through the sclera into the vitreous. Different IOP levels were maintained by varied amounts of Healon GV injections into the anterior chamber. The changes of vitreous pH values following the intracameral injections were recorded and evaluated. The changes of vitreous pH values were minimal when IOPs were maintained at lower than 35 mmHg. Vitreous pH values decreased significantly from 7.32 to less than 7.03, when the IOPs were kept at 70 mmHg or higher. However, the decrease of pH values was reversible if IOP was held at 70 mmHg for less than 10 minutes and then reduced to normal level at once. In addition, with MTT viability assay, it wasnoted that the decrease in vitreous pH was associated with a higher percentage of retinal cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:26:17