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Titolo:
In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyricacid-glutamine cycling in rodent and human cortex: the central role of glutamine
Autore:
Behar, KL; Rothman, DL;
Indirizzi:
Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 , Dept Psychiat, New Haven, CT 06520 USA Yale Univ, Sch Med, Dept Diagnost Radiol, Magnet Resonance Ctr Res Metab &Physiol, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 Metab &Physiol, New Haven, CT 06520 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 9, volume: 131, anno: 2001, supplemento:, S
pagine: 2498S - 2504S
SICI:
0022-3166(200109)131:9<2498S:IVNMRS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-MEMBRANE TRANSPORTER; RAT-BRAIN INVIVO; C-13 NMR; CEREBRAL-CORTEX; METABOLIC COMPARTMENTATION; EXOGENOUS GLUTAMATE; ENERGY-METABOLISM; NEURONAL-ACTIVITY; HYPERAMMONEMIC RAT; PRIMARY CULTURES;
Keywords:
glutamine; glutamate-glutamine cycle; neuron; astrocyte trafficking; NMR; cerebral glucose utilization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Behar, KL Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 chiat, New Haven, CT 06520 USA
Citazione:
K.L. Behar e D.L. Rothman, "In vivo nuclear magnetic resonance studies of glutamate-gamma-aminobutyricacid-glutamine cycling in rodent and human cortex: the central role of glutamine", J NUTR, 131(9), 2001, pp. 2498S-2504S

Abstract

It has been recognized for many years that the metabolism of brain glutamate and gamma -aminobutyric acid (GABA), the major excitatory and inhibitoryneurotransmitters, Is linked to a substrate cycle between neurons and astrocytes involving glutamine. However, the quantitative significance of thesefluxes in vivo was not known. Recent in vivo C-13 and N-15 NMR studies in rodents and C-13 NMR in humans indicate that glutamine synthesis is substantial and that the total glutamate-GABA-glutamine cycling flux, necessary toreplenish neurotransmitter glutamate and GABA, accounts for > 80% of net glutamine synthesis. In studies of the rodent cortex, a linear relationship exists between the rate of glucose oxidation and total glutamate-GABA-glutamine cycling flux over a large range of cortical electrical activity. The molar stoichiometric relationship (similar to1:1) found between these fluxessuggests that they share a common mechanism and that the glutamate-GABA-glutamine cycle is coupled to a major fraction of cortical glucose utilization. Thus, glutamine appears to play a central role in the normal functional energetics of the cerebral cortex.

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Documento generato il 05/04/20 alle ore 04:04:57