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Titolo:
Amino acid regulation of gene expression
Autore:
Jefferson, LS; Kimball, SR;
Indirizzi:
Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 & Mol Physiol, Hershey, PA 17033 USA
Titolo Testata:
JOURNAL OF NUTRITION
fascicolo: 9, volume: 131, anno: 2001, supplemento:, S
pagine: 2460S - 2466S
SICI:
0022-3166(200109)131:9<2460S:AAROGE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE EXCHANGE FACTOR; P70 S6 KINASE; PROTEIN PHOSPHATASE 2A; EUKARYOTIC INITIATION FACTOR-2-ALPHA; POLYPEPTIDE-CHAIN INITIATION; GLYCOGEN-SYNTHASE KINASE-3; SMOOTH-MUSCLE CELLS; PERFUSED-RAT-LIVER; PHAS-I; TRANSLATION INITIATION;
Keywords:
leucine; translation initiation; signal transduction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Jefferson, LS Penn State Univ, Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 Hershey, PA 17033 USA
Citazione:
L.S. Jefferson e S.R. Kimball, "Amino acid regulation of gene expression", J NUTR, 131(9), 2001, pp. 2460S-2466S

Abstract

Regulation of gene expression by amino acids is mediated through a number of mechanisms affecting both the transcription of DNA and the translation of mRNA. This report reviews recent findings demonstrating a role for amino acids in regulating the initiation phase of mRNA translation. The report focuses on key regulatory events in translation initiation and discusses someof the signaling pathways through which amino acid sufficiency or the lackthereof is communicated within the cell. It concludes with a considerationof some of the important unanswered questions in this rapidly advancing area of research.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 05:12:54