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Titolo:
Acceleration of HIV dementia with methamphetamine and cocaine
Autore:
Nath, A; Maragos, WF; Avison, MJ; Schmitt, FA; Berger, JR;
Indirizzi:
Univ Kentucky, Dept Neurol, Lexington, KY 40526 USA Univ Kentucky Lexington KY USA 40526 Dept Neurol, Lexington, KY 40526 USA Univ Kentucky, Dept Microbiol & Immunol, Lexington, KY 40526 USA Univ Kentucky Lexington KY USA 40526 l & Immunol, Lexington, KY 40526 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 66 - 71
SICI:
1355-0284(200102)7:1<66:AOHDWM>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; INTRAVENOUS-DRUG-USERS; AIDS DEMENTIA; NEUROPSYCHOLOGICAL PERFORMANCE; ANTIRETROVIRAL THERAPY; STRIATAL DOPAMINE; HOMOSEXUAL MEN; BASAL GANGLIA; TAT; NEUROTOXICITY;
Keywords:
HIV; brain; AIDS; cocaine; methamphetamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Nath, A Univ Kentucky, Dept Neurol, Lexington, KY 40526 USA Univ KentuckyLexington KY USA 40526 rol, Lexington, KY 40526 USA
Citazione:
A. Nath et al., "Acceleration of HIV dementia with methamphetamine and cocaine", J NEUROVIRO, 7(1), 2001, pp. 66-71

Abstract

We report a patient with rapidly accelerating HIV dementia accompanied by seizures and an unusual movement disorder despite highly potent antiretroviral therapy. This clinical constellation was associated with the non-parenteral use of methamphetamine and cocaine. Fractional enhancement time on post contrast magnetic resonance imaging studies revealed a progressive breakdown of the blood brain barrier particularly in the basal ganglia. The movement disorder but not the dementia responded to a combination of dopamine replacement and anticholinergic therapy. While the movement disorder may havebeen unmasked by concomitant anticonvulsant therapy, we suggest in this instance, that prior drug abuse synergized with HIV to cause a domino effect on cerebral function. Careful attention and analysis to histories of remotenoninjecting drug abuse may help substantiate our hypothesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 19:35:11