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Titolo:
Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat
Autore:
Smith, DG; Guillemin, GJ; Pemberton, L; Kerr, S; Nath, A; Smythe, GA; Brew, BJ;
Indirizzi:
St Vincents Hosp, Ctr Immunol, Darlinghurst, NSW 2010, Australia St Vincents Hosp Darlinghurst NSW Australia 2010 rst, NSW 2010, Australia Univ Kentucky, Dept Neurol, Lexington, KY USA Univ Kentucky Lexington KY USA Kentucky, Dept Neurol, Lexington, KY USA Univ New S Wales, Ray Williams Biomed Mass Spectrometry Facil, Sydney, NSW2052, Australia Univ New S Wales Sydney NSW Australia 2052 il, Sydney, NSW2052, Australia Natl Ctr HIV Epidemiol & Clin Res, Darlinghurst, NSW 2010, Australia Natl Ctr HIV Epidemiol & Clin Res Darlinghurst NSW Australia 2010 stralia St Vincents Hosp, Dept HIV, Darlinghurst, NSW 2010, Australia St Vincents Hosp Darlinghurst NSW Australia 2010 rst, NSW 2010, Australia St Vincents Hosp, Dept Neurol, Darlinghurst, NSW 2010, Australia St Vincents Hosp Darlinghurst NSW Australia 2010 rst, NSW 2010, Australia
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 56 - 60
SICI:
1355-0284(200102)7:1<56:QAIPBM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1 INFECTION; NEUROTOXICITY; ASTROCYTES; DEMENTIA; PATHWAY; BRAIN; PROTECTION; METABOLISM; TRYPTOPHAN;
Keywords:
HIV-1; ADC; kynurenine pathway;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, DG St Vincents Hosp, Ctr Immunol, Darlinghurst, NSW 2010, AustraliaSt Vincents Hosp Darlinghurst NSW Australia 2010 010, Australia
Citazione:
D.G. Smith et al., "Quinolinic acid is produced by macrophages stimulated by platelet activating factor, Nef and Tat", J NEUROVIRO, 7(1), 2001, pp. 56-60

Abstract

Activated macrophages produce quinolinic acid (QUIN), a neurotoxin, in several inflammatory brain diseases including AIDS dementia complex. We hypothesized that IL1-beta, IL6, transforming growth factor (TGF-beta (2)) and platelet activating factor could increase macrophage QUIN production. And that the HIV-1 proteins Nef, Tat and gp41 may also increase synthesis of QUIN by macrophages. At 72 h there were significant increases in QUIN productionin the cells stimulated with PAF (914 +/- 50 nM) and Nef (2781 +/- 162 nM), with somewhat less production by Tat stimulation (645 +/- 240 nM). The increases in QUIN production approximated in vitro concentrations of QUIN shown to be neurotoxic and correlated closely with indoleamine 2,3-dioxygenaseinduction. IL1-beta, IL6, TGF-beta (2) and gp41 stimulation produced no significant increase fil QUIN production. These results suggest that some of the neurotoxicity ofPAF, nef and tat maybe mediated by QUIN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:11:40