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Titolo:
Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture
Autore:
Perez, A; Probert, AW; Wang, KKW; Sharmeen, L;
Indirizzi:
Parke Davis Pharmaceut Res, Dept Infect Dis, Ann Arbor, MI 48105 USA ParkeDavis Pharmaceut Res Ann Arbor MI USA 48105 Ann Arbor, MI 48105 USA Parke Davis Pharmaceut Res, Dept Neurosci Therapeut, Ann Arbor, MI 48105 USA Parke Davis Pharmaceut Res Ann Arbor MI USA 48105 Ann Arbor, MI 48105 USA
Titolo Testata:
JOURNAL OF NEUROVIROLOGY
fascicolo: 1, volume: 7, anno: 2001,
pagine: 1 - 10
SICI:
1355-0284(200102)7:1<1:EOHTIN>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; RECEPTOR-MEDIATED NEUROTOXICITY; TRANSACTIVATING PROTEIN TAT; CENTRAL-NERVOUS-SYSTEM; NECROSIS-FACTOR-ALPHA; MAEDI-VISNA VIRUS; AIDS DEMENTIA; COAT PROTEIN; HIPPOCAMPAL-NEURONS; OXIDATIVE STRESS;
Keywords:
neuronal cell death; HIV-1; Tat; NMDA receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Sharmeen, L Parke Davis Pharmaceut Res, Dept Infect Dis, 2800 Plymouth Rd,Ann Arbor, MI 48105 USA Parke Davis Pharmaceut Res 2800 Plymouth Rd Ann Arbor MI USA 48105
Citazione:
A. Perez et al., "Evaluation of HIV-1 Tat induced neurotoxicity in rat cortical cell culture", J NEUROVIRO, 7(1), 2001, pp. 1-10

Abstract

In a substantial number of cases, Human Immunodeficiency Virus type 1 (HIV-1) infection causes neuronal cell loss and leads to the development of AIDS associated dementia. Several studies have suggested that both host and viral factors contribute to neuronal loss. Here we studied the effect of HIV-1 Tat in primary rat neuronal cells as a model to understand mechanism of neuronal cell death. At nano molar concentration, recombinant Tat induced cell death in primary rat mixed cortical neurons. Tat could also induce uptake of calcium in primary rat cultures. When cells were incubated with NMDA receptor antagonists, MK-801 and D-CPP, cell death and Ca-45 uptake were inhibited. Under similar conditions non-NMDA antagonists, NBQX, DNQX and CNQX,and sodium channel antagonist, TTX, did not inhibit Tat induced neuronal cell death. In a similar way HIV associated products from in vitro HIV-1 infected cells induced neuronal cell death which was inhibited by NMDA receptor antagonist. Results presented in this paper suggest that activation of NMDA receptors by HIV-1 Tat is responsible for neuronal cell death in primaryrat cortical neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:39:08