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Titolo:
Correlation of AMPA receptor subunit composition with synaptic input in the mammalian cochlear nuclei
Autore:
Gardner, SM; Trussell, LO; Oertel, D;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Physiol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Physiol, Madison, WI 53706 USA Oregon Hlth Sci Univ, Vollum Inst, Oregon Hearing Res Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 es Ctr, Portland, OR 97201 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 18, volume: 21, anno: 2001,
pagine: 7428 - 7437
SICI:
0270-6474(20010915)21:18<7428:COARSC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALCIUM-BINDING PROTEINS; AUDITORY BRAIN-STEM; COMPLEX-SPIKING NEURONS; GLUTAMATE-RECEPTOR; CA2+ PERMEABILITY; STELLATE CELLS; OCTOPUS CELLS; INTRACELLULAR-RECORDINGS; HORSERADISH-PEROXIDASE; INWARD RECTIFICATION;
Keywords:
AMPA receptor; auditory pathways; GluR2; polyamine; rectification; kinetics; flop; cochlear nuclei; cyclothiazide; deactivation; desensitization; targeting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Oertel, D Univ Wisconsin, Sch Med, Dept Physiol, 1300 Univ Ave, Madison, WI 53706 USA Univ Wisconsin 1300 Univ Ave Madison WI USA 53706 , WI 53706 USA
Citazione:
S.M. Gardner et al., "Correlation of AMPA receptor subunit composition with synaptic input in the mammalian cochlear nuclei", J NEUROSC, 21(18), 2001, pp. 7428-7437

Abstract

The composition of AMPA receptors in patches excised from somata and dendrites of six cell types In the mammalian cochlear nuclei was probed and compared electrophysiologically and pharmacologically with the rapid application of glutamate. Cells excited predominantly by auditory nerve fibers had AMPA receptors with exceptionally rapid gating (submillisecond deactivation and desensitization time constants). The nonlinear current-voltage relationship In the presence of spermine showed that few of these receptors had GluR2 subunits, and the insensitivity of desensitization to cyclothiazide indicated that they contained mostly flop splice variants. At synapses made by parallel fibers, AMPA receptors were slowly gating (time constants of deactivation and desensitization > 1 msec) and contained higher levels of GluR2 and flip isoforms. However, receptors at auditory nerve synapses on cells that also receive parallel fiber input, the fusiform cells, had intermediate properties with respect to kinetics and contained GluR2 and flip isoforms. Given the diverse biophysical properties, patterns of innervation, patternsof electrical activity, and targets of each cell type in vivo, these data indicate that the kinetics and permeation properties of AMPA receptors are linked to factors associated with synaptic connectivity.

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Documento generato il 01/06/20 alle ore 02:36:54