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Titolo:
Expression of Golli mRNA during development in primary immune lymphoid organs of the rat
Autore:
Skorupa, AF; Brezinski, SCG; Lesh, G; Heber-Katz, E; McMorris, FA;
Indirizzi:
Wistar Inst Anat & Biol, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol Philadelphia PA USA 19104 ladelphia, PA 19104 USA
Titolo Testata:
JOURNAL OF NEUROIMMUNOLOGY
fascicolo: 1, volume: 119, anno: 2001,
pagine: 64 - 72
SICI:
0165-5728(20010903)119:1<64:EOGMDD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN BASIC-PROTEIN; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CENTRAL-NERVOUS-SYSTEM; T-CELL DEVELOPMENT; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; PROTEOLIPID PROTEIN; MULTIPLE-SCLEROSIS; LEWIS RATS; ANTIGENIC DETERMINANTS; GENE;
Keywords:
Lewis rat; primary lymphoid organs; Golli-MBP; T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Heber-Katz, E Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA Wistar Inst Anat & Biol 3601 Spruce St Philadelphia PA USA 19104
Citazione:
A.F. Skorupa et al., "Expression of Golli mRNA during development in primary immune lymphoid organs of the rat", J NEUROIMM, 119(1), 2001, pp. 64-72

Abstract

The gene-of-the-oligodendrocyte lineage (Golli)-MBP transcription unit contains three Golli-specific exons together with eight exons of the "classical" myelin basic protein (MBP) gene, yielding alternatively spliced proteinswhich share amino acid sequence with MBP. Unlike MBP, a late antigen expressed only in the nervous system, Golli gene products are expressed pre- andpost-natally at many sites. In this study, we determined the sequence of Golli in rat by RT-PCR and 5' RACE and showed that Golli sequences are expressed in primary lymphoid organs as early as e16.5. which could explain the anergic rat T cell response we previously observed in Golli-induced meningitis. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:50:29