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Titolo:
ODC mRNA as a prognostic factor for predicting recurrence in meningiomas
Autore:
Klekner, A; Rohn, G; Schillinger, G; Schroder, R; Klug, N; Ernestus, RI;
Indirizzi:
Univ Cologne, Neurochirurg Klin, Dept Neurosurg, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 Neurosurg, D-50924 Cologne, Germany Univ Cologne, Dept Neuropathol, D-50924 Cologne, Germany Univ Cologne Cologne Germany D-50924 uropathol, D-50924 Cologne, Germany
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 1, volume: 53, anno: 2001,
pagine: 67 - 75
SICI:
0167-594X(2001)53:1<67:OMAAPF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
DECARBOXYLASE MESSENGER-RNA; ORNITHINE DECARBOXYLASE; POLYAMINE METABOLISM; MALIGNANCY; TUMORS; PROGRESSION; EXPRESSION; GENETICS; PROTEIN; GLIOMAS;
Keywords:
meningiomas; ornithine decarboxylase (ODC); mRNA; Ki-67; mitoses; recurrence; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ernestus, RI Univ Cologne, Neurochirurg Klin, Dept Neurosurg, Joseph Stelzmann Str 9, D-50924 Cologne, Germany Univ Cologne Joseph Stelzmann Str 9 Cologne Germany D-50924
Citazione:
A. Klekner et al., "ODC mRNA as a prognostic factor for predicting recurrence in meningiomas", J NEURO-ONC, 53(1), 2001, pp. 67-75

Abstract

In proliferating neoplastic cells, activity of the enzyme ornithine decarboxylase (ODC) increases. Among other brain tumors, ODC activation could also be observed in meningiomas. In the present study, we have investigated ODC gene expression in primary and recurrent meningiomas at the transcriptional level. ODC mRNA (messenger ribonucleic acid), ODC activity, number of mitoses, and Ki-67 index as a marker for nuclear proliferation were quantified in three different groups of meningiomas: tumors without recurrence in a 8.4 yearsmedian follow-up period, tumors with recurrence within a median follow-up of 3.0 years, and their corresponding recurrent tumors. ODC mRNA level was significantly higher in meningiomas with later recurrence as compared to meningiomas without recurrence (p less than or equal to 0.01), whereas it declined in the recurrences of the second group (p less than or equal to 0.001). In contrast, ODC activity showed no difference between the two groups of primary tumors, but a significant increase of enzyme activity could be observed in the recurrences as compared to the correponding primary tumors (p less than or equal to 0.001). Likewise, an increase of the Ki-67 index could be detected in the recurrent group (p less than or equal to 0.001). These results suggest that ODC mRNA may represent a prognostic factor for predicting recurrence in meningiomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:36:34