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Titolo:
Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells
Autore:
Terui, T; Sano, K; Okada, M; Shirota, H; Honda, M; Ozawa, M; Hirasawa, N; Tamura, G; Tagami, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Dermatol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Internal Med 1, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 rnal Med 1, Sendai, Miyagi 980, Japan Tohoku Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol Biochem, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 ol Biochem, Sendai, Miyagi 980, Japan
Titolo Testata:
JOURNAL OF INVESTIGATIVE DERMATOLOGY
fascicolo: 2, volume: 117, anno: 2001,
pagine: 236 - 243
SICI:
0022-202X(200108)117:2<236:PAPMOT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
DELAYED-TYPE HYPERSENSITIVITY; RECEPTOR TRANSGENIC MICE; MESSENGER-RNA EXPRESSION; TUMOR-NECROSIS-FACTOR; CD4+ T-CELLS; ADHESION MOLECULE-1; ATOPIC-DERMATITIS; MYCOBACTERIUM-TUBERCULOSIS; FUNCTIONAL-PROPERTIES; TISSUE INFLAMMATION;
Keywords:
eosinophil; FK-506; neutrophil; Th1; Th2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Terui, T Tohoku Univ, Sch Med, Dept Dermatol, Aoba Ku, Seiryo Machi 1-1, Sendai, Miyagi 9808574, Japan Tohoku Univ Seiryo Machi 1-1 Sendai Miyagi Japan 9808574 4, Japan
Citazione:
T. Terui et al., "Production and pharmacologic modulation of the granulocyte-associated allergic responses to ovalbumin in murine skin models induced by injecting ovalbumin-specific Th1 or Th2 cells", J INVES DER, 117(2), 2001, pp. 236-243

Abstract

Because interferon-gamma, interleukin-4, and interleukin-5 have been identified at the mRNA and protein levels in the lesional skin of patients with atopic dermatitis, we investigated the roles played by granulocytes as effector cells in allergic inflammation by using two unique murine skin models. In vitro generated Th1 and Th2 cells from naive splenocytes of antiovalbumin T cell receptor transgenic BALB/C mice were adoptively transferred with ovalbumin into the ear pinnae or air-pouches produced in the back skin of naive, nontransgenic BALB/C mice. The injection of Th1 cells with ovalbumin induced delayed type ear swelling that peaked at 48 h, whereas that of Th2 resulted in ear swelling that peaked at a much earlier time, 24 h. Histologic study of the swollen ear skin and granulocytes recruited into the air-pouch demonstrated that, although the Th1-induced inflammation caused a neutrophil-predominant infiltrate with few eosinophils, larger numbers of eosinophils accumulated in the Th2-induced inflammation. Using these murine models, we further evaluated the effects of drugs used for the treatment of atopic diseases. The results showed that FK506 administration could effectivelyreduce skin inflammation induced by either Th cells. Interestingly, the neutrophil elastase inhibitor ONO-6818 efficiently inhibited Th1-induced inflammation. In contrast, a leukotriene receptor antagonist, ONO-1078, specifically suppressed Th2-induced inflammation. We also found that each ONO drugexerted direct influence on specified granulocytes, as neither affected invitro production of relevant Th cytokines. Thus, we succeeded in developing animal skin inflammation models in which we can evaluate the contributionof protein antigen-specific Th1 or Th2 cells through the action of granulocytic effector cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:09:27