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Titolo:
Treatment of abdominally obese men with a serotonin reuptake inhibitor: a pilot study
Autore:
Ljung, T; Ahlberg, AC; Holm, G; Friberg, P; Andersson, B; Eriksson, E; Bjorntorp, P;
Indirizzi:
Sahlgrens Univ Hosp, Dept Heart & Lung Dis, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Psychiat, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Sahlgrens Univ Hosp, Dept Med, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 -41345 Gothenburg, Sweden Univ Gothenburg, Dept Pharmacol, Gothenburg, Sweden Univ Gothenburg Gothenburg Sweden g, Dept Pharmacol, Gothenburg, Sweden
Titolo Testata:
JOURNAL OF INTERNAL MEDICINE
fascicolo: 3, volume: 250, anno: 2001,
pagine: 219 - 224
SICI:
0954-6820(200109)250:3<219:TOAOMW>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-FAT DISTRIBUTION; DEPENDENT DIABETES-MELLITUS; PITUITARY-ADRENAL AXIS; CORTISOL SECRETION; INSULIN-RESISTANCE; DEPRESSED-PATIENTS; RISK-FACTORS; SYSTEM; STRESS; RATIO;
Keywords:
abdominal obesity; depression; hypothalamic-pituitary-adrenal axis; serotonin reuptake inhibition; sympathetic nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Ljung, T Sahlgrens Univ Hosp, Dept Heart & Lung Dis, SE-41345 Gothenburg, Sweden Sahlgrens Univ Hosp Gothenburg Sweden SE-41345 thenburg, Sweden
Citazione:
T. Ljung et al., "Treatment of abdominally obese men with a serotonin reuptake inhibitor: a pilot study", J INTERN M, 250(3), 2001, pp. 219-224

Abstract

Objective. To investigate the effects of a selective serotonin reuptake inhibitor (SSRI) on the neuroendocrine and autonomic nervous system perturbations found in abdominal obesity. Design. Treatment for 6 months with citalopram and for 6 months with placebo using a double-blind, cross-over design, with a 2-month wash-out period between treatment periods. Subjects. Sixteen healthy men, 45-60 years, moderately obese and with an abdominal fat distribution. Measurements. Anthropometry, three different depression rating scales, serum lipids, testosterone, IGF-I, oral glucose tolerance test (OGTT), pituitary stimulation with corticotropin releasing hormone (CRH), arithmetic stress test, and excretion of cortisol and metoxycatecholamines in urine, collected during 24 h. Results. Cortisol concentrations in the morning were low before treatment,indicating a perturbed function of the hypothalamic-pituitary-adrenal (HPA) axis. After treatment with citalopram morning cortisol concentrations rose to normal. Cortisol concentrations after stimulation with CRH or stress were elevated by citalopram treatment, but urinary cortisol excretion was unchanged. The glucose concentrations after OGTT (120 min) tended to be reduced, with unchanged insulin concentrations, whilst other metabolic values did not change during treatment. Heart rate after administration of CRH, and during laboratory stress test, decreased by treatment with citalopram. Diurnal urinary excretion of metoxycatecholamines tended to decrease. Neither body mass index nor waist/hip circumference ratio decreased. Depression scores were within normal limits before treatment and did not change. Conclusion. The results of this pilot study indicate improvements in the regulation of neuroendocrine-autonomic systems as well as metabolism in abdominal obesity during treatment with an SSRI.

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Documento generato il 22/01/20 alle ore 12:36:05