Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Impairment of CD8(+) T suppressor cell function in patients with active systemic lupus erythematosus
Autore:
Filaci, G; Bacilieri, S; Fravega, M; Monetti, M; Contini, P; Ghio, M; Setti, M; Puppo, F; Indiveri, F;
Indirizzi:
Univ Genoa, Dipartimento Med Interna, Div Internal Med & Clin Immunol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 Med & Clin Immunol, I-16132 Genoa, Italy
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 166, anno: 2001,
pagine: 6452 - 6457
SICI:
0022-1767(20010515)166:10<6452:IOCTSC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYASTHENIA-GRAVIS; LYMPHOCYTES; MECHANISMS; CYTOKINES; ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Indiveri, F Univ Genoa, Dipartimento Med Interna, Div Internal Med & Clin Immunol, Viale Benedetto XV 6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto XV 6 Genoa Italy I-16132 oa, Italy
Citazione:
G. Filaci et al., "Impairment of CD8(+) T suppressor cell function in patients with active systemic lupus erythematosus", J IMMUNOL, 166(10), 2001, pp. 6452-6457

Abstract

Alteration of T cell suppression function has been recognized in patients with systemic lupus erythematosus (SLE). Recently, CD8(+) T suppressor lymphocytes (CD8+ Ts) have been generated in vitro by incubating purified CD8(+) T cells with IL-2 and GM-CSF. Using this method, we generated CD8(+) Ts from patients affected by SLE. No major differences were found in the CD8(+)Ts phenotype between SLE patients and healthy subjects. CD8(+) Ts from SLEpatients with active disease did not inhibit the anti-CD3 mAb-induced proliferation of autologous PBMC, whereas CD8(+) Ts from SLE patients in remission exerted an inhibitory activity comparable to normal subjects. The inhibitory effect of CD8(+) Ts cells was neither mediated by cytotoxic activity nor by apoptosis induction. Two cytokines, IFN-gamma and IL-6, were found to be responsible for the function of CD8(+) Ts. In fact, counteraction of CD8(+) Ts suppression activity was obtained by blocking IFN-gamma with a specific Ab or by inhibiting CD8(+) Ts-mediated IL-6 secretion by an antisenseoligonucleotide. Interestingly, CD8(+) Ts from SLE patients showed a peculiar cytokine pattern characterized by an impaired secretion of IL-6 and an increased secretion of IL-12. Thus, it appears that an altered balance between inhibitory (IL-6) and stimulatory (IL-12) cytokines might be responsible for the functional impairment of CD8(+) Ts in SLE patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 22:49:15