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Titolo:
Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B
Autore:
Vidarsson, G; van der Pol, WL; van den Elsen, JMH; Vile, H; Jansen, M; Duijs, J; Morton, HC; Boel, E; Daha, MR; Corthesy, B; van de Winkel, JGJ;
Indirizzi:
Univ Utrecht, Med Ctr, Dept Immunol, Immunotherapy Lab, NL-3584 EA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 EA 3584 EA Utrecht, Netherlands Univ Utrecht, Med Ctr, Medarex Europe, NL-3584 EA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 EA 3584 EA Utrecht, Netherlands Univ Utrecht, Med Ctr, Genmab, NL-3584 EA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 EA 3584 EA Utrecht, Netherlands Univ Utrecht, Med Ctr, Eijkman Winkler Inst Microbiol Infect Dis & Infla, NL-3584 EA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3584 EA 3584 EA Utrecht, Netherlands Univ Toronto, Dept Med Biophys, Toronto, ON, Canada Univ Toronto Toronto ON Canada to, Dept Med Biophys, Toronto, ON, Canada Ontario Canc Inst, Toronto, ON M4X 1K9, Canada Ontario Canc Inst Toronto ON Canada M4X 1K9 , Toronto, ON M4X 1K9, Canada Leiden Univ, Med Ctr, Dept Nephrol, Leiden, Netherlands Leiden Univ Leiden Netherlands d Ctr, Dept Nephrol, Leiden, Netherlands Univ Oslo, Natl Hosp, Lab Immunohistochem & Immunopathol, Oslo, Norway Univ Oslo Oslo Norway Lab Immunohistochem & Immunopathol, Oslo, Norway CHU Vaudois, Div Immunol & Allergie, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 166, anno: 2001,
pagine: 6250 - 6256
SICI:
0022-1767(20010515)166:10<6250:AOHIAI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERICIDAL ANTIBODY RECOGNITION; SECRETORY IMMUNOGLOBULIN-A; MEMBRANE VESICLE VACCINE; FC-ALPHA-R; MONOCLONAL-ANTIBODIES; MENINGOCOCCAL DISEASE; CHIMERIC ANTIBODIES; RECEPTOR; COMPLEMENT; PORA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: van de Winkel, JGJ Univ Utrecht, Med Ctr, Dept Immunol, Immunotherapy Lab,Room KC-02-085-2,Lundlaan 6, NL-3584 EA Utrecht, Netherlands Univ Utrecht Room KC-02-085-2,Lundlaan 6 Utrecht Netherlands NL-3584 EA
Citazione:
G. Vidarsson et al., "Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B", J IMMUNOL, 166(10), 2001, pp. 6250-6256

Abstract

Both IgG and IgA Abs have been implicated in host defense against bacterial infections, although their relative contributions remain unclear. We generated a unique panel of human chimeric Abs of all human IgG and IgA subclasses with identical V genes against porin A, a major subcapsular protein Ag of Neisseria meningitidis and a vaccine candidate. Chimeric Abs were produced in baby hamster kidney cells, and IgA-producing clones were cotransfected with human J chain and/or human secretory component. Although IgG (isotypes IgG1-3) mediated efficient complement-dependent lysis, IgA was unable to. However, IgA proved equally active to IgG in stimulating polymorphonuclear leukocyte respiratory burst. Remarkably, although porin-specific monomeric, dimeric, and polymeric IgA triggered efficient phagocytosis, secretory IgA did not. These studies reveal unique and nonoverlapping roles for IgG and IgA Abs in defense against meningococcal infections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:44:26