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Titolo:
Cutting edge: Antigen-independent CD8 T cell proliferation
Autore:
Wong, P; Pamer, EG;
Indirizzi:
Mem Sloan Kettering Canc Ctr, Infect Dis Serv, New York, NY 10021 USA Mem Sloan Kettering Canc Ctr New York NY USA 10021 New York, NY 10021 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 10, volume: 166, anno: 2001,
pagine: 5864 - 5868
SICI:
0022-1767(20010515)166:10<5864:CEACTC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BACTERIAL-INFECTION; IN-VIVO; P27(KIP1) EXPRESSION; CYCLE PROGRESSION; MEMORY; HOMEOSTASIS; GAMMA; STIMULATION; EXPANSION; IMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Pamer, EG Mem Sloan Kettering Canc Ctr, Infect Dis Serv, 1275 York Ave, New York, NY10021 USA Mem Sloan Kettering Canc Ctr 1275 York Ave New York NY USA 10021
Citazione:
P. Wong e E.G. Pamer, "Cutting edge: Antigen-independent CD8 T cell proliferation", J IMMUNOL, 166(10), 2001, pp. 5864-5868

Abstract

Recent analyses of CD8 T cell responses to Listeria monocytogenes infection demonstrate that the duration of in vivo T cell proliferation is not determined by the amount or duration of Ag presentation. However, the extent towhich T lymphocytes are capable of proliferating in the absence of Ag is unknown. Herein we demonstrate that CD8 T lymphocytes undergo up to eight rounds of proliferation in the absence of Ag following transient, 2.5-h in vitro antigenic stimulation. Ag-independent expansion of CD8 T cells is driven by IL-2 and is further augmented by IL-7 or IL-15. These experiments clearly demonstrate that CD8 T cells undergo prolonged proliferation following transient Ag exposure and support the notion that in vivo CD8 T cell expansion following infection can be uncoupled from Ag presentation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:55:40