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Titolo:
The role of the CD19/CD21 complex in B cell processing and presentation ofcomplement-tagged antigens
Autore:
Cherukuri, A; Cheng, PC; Pierce, SK;
Indirizzi:
NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA NIAID Rockville MD USA 20852 mmunogenet Lab, NIH, Rockville, MD 20852 USA Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA Northwestern Univ Evanston IL USA 60208 Cell Biol, Evanston, IL 60208 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 1, volume: 167, anno: 2001,
pagine: 163 - 172
SICI:
0022-1767(20010701)167:1<163:TROTCC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMORAL IMMUNE-RESPONSE; T-DEPENDENT ANTIGEN; CROSS-LINKING; CLASS-II; ACQUIRED-IMMUNITY; RECEPTOR; LYMPHOCYTES; EXPRESSION; MICE; CD19;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pierce, SK NIAID, Immunogenet Lab, NIH, Twinbrook 2,12441 Parklawn Dr,Room200B,MSC 8180, Rockville, MD 20852 USA NIAID Twinbrook 2,12441 Parklawn Dr,Room 200B,MSC 8180 Rockville MD USA 20852
Citazione:
A. Cherukuri et al., "The role of the CD19/CD21 complex in B cell processing and presentation ofcomplement-tagged antigens", J IMMUNOL, 167(1), 2001, pp. 163-172

Abstract

The CD19/CD21 complex is an essential B cell coreceptor that functions synergistically to enhance signaling through the B cell Ag receptor in response to T cell-dependent, complement-tagged Ags. In this study, we use a recombinant protein containing three tandemly arranged copies of Od and the Ag hen egg lysozyme, shown to be a highly effective immunogen in vivo, to evaluate the role of the CD19/CD21 complex in Ag processing in B cells. Evidenceis provided that coengagement of the CD19/CD21 complex results in more rapid and efficient production of antigenic peptide/class II complexes as compared with B cell Ag receptor-mediated processing alone. The CD19/CD21 complex does not itself target complement-tagged Ags for processing, but rather appears to influence B cell Ag processing through its signaling function. The ability of the CD19/CD21 complex to augment processing may be an important element of the mechanism by which the CD19/CD21 complex functions to promote B cell responses to T cell-dependent complement-tagged Ags in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:41:10