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Titolo:
Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection
Autore:
Simpson, AJ; Wallace, WAH; Marsden, ME; Govan, JRW; Porteous, DJ; Haslett, C; Sallenave, JM;
Indirizzi:
Univ Edinburgh, Sch Med, Rayne Lab, Resp Med Unit,MRC Ctr Inflammat Res, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh MidlothianScotland EH8 9AG Midlothian, Scotland Univ Edinburgh, Sch Med, Dept Microbiol, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland No Gen Hosp, Dept Pathol, Sheffield S5 7AU, S Yorkshire, England No Gen Hosp Sheffield S Yorkshire England S5 7AU AU, S Yorkshire, England Univ Edinburgh, Mol Med Ctr, Med Genet Sect, Western Gen Hosp, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 167, anno: 2001,
pagine: 1778 - 1786
SICI:
0022-1767(20010801)167:3<1778:AAOEPT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELASTASE-SPECIFIC INHIBITOR; LEUKOCYTE PROTEINASE-INHIBITOR; RESPIRATORY-DISTRESS SYNDROME; ALVEOLAR EPITHELIAL-CELLS; PSEUDOMONAS-AERUGINOSA; HOST-DEFENSE; GENE-THERAPY; PEPTIDE ANTIBIOTICS; PROTEASE INHIBITOR; CYSTIC-FIBROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Sallenave, JM Univ Edinburgh, Sch Med, Rayne Lab, Resp Med Unit,MRC Ctr Inflammat Res, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG otland
Citazione:
A.J. Simpson et al., "Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection", J IMMUNOL, 167(3), 2001, pp. 1778-1786

Abstract

During acute pulmonary infection, tissue injury may be secondary to the effects of bacterial products or to the effects of the host inflammatory response. An attractive strategy for tissue protection. in this setting would combine antimicrobial activity with inhibition of human neutrophil elastase (HNE), a key effector of neutrophil-mediated tissue injury. We postulated that genetic augmentation of elafin (an endogenous inhibitor of HNE with intrinsic antimicrobial activity) could protect the lung against acute inflammatory injury without detriment to host defense. A replication-deficient adenovirus encoding elafin cDNA significantly protected A549 cells against theinjurious effects of both HNE and whole activated human neutrophils in vitro. Intratracheal replication-deficient adenovirus encoding elafin cDNA significantly protected murine lungs against injury mediated by Pseudomonas aeruginosa in vivo. Genetic augmentation of elafin therefore has the capacityto protect the lung against the injurious effects of both bacterial pathogens resistant to conventional antibiotics and activated neutrophils.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:04:43