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Titolo:
4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy
Autore:
Cannons, JL; Lau, P; Ghumman, B; DeBenedette, MA; Yagita, H; Okumura, K; Watts, TH;
Indirizzi:
Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 munol, Toronto, ON M5S 1A8, Canada Juntendo Univ, Sch Med, Dept Immunol, Tokyo 113, Japan Juntendo Univ Tokyo Japan 113 v, Sch Med, Dept Immunol, Tokyo 113, Japan
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 3, volume: 167, anno: 2001,
pagine: 1313 - 1324
SICI:
0022-1767(20010801)167:3<1313:4LICDS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
M12 B-LYMPHOMAS; FACTOR-KAPPA-B; CO-STIMULATION; COSTIMULATORY MOLECULE; MICE LACKING; OX40 LIGAND; IN-VIVO; RECEPTOR; ANTIGEN; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Watts, TH Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 onto, ON M5S 1A8, Canada
Citazione:
J.L. Cannons et al., "4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy", J IMMUNOL, 167(3), 2001, pp. 1313-1324

Abstract

A costimulatory member of the TNFR family, 4-1BB, is expressed on activated T cells. Although some reports have suggested that 4-1BB is primarily involved in CD8 T cell activation, in this report we demonstrate that both CD4and CD8 T cells respond to 4-1BB ligand (4-1BBL) with similar efficacy. CD4 and CD8 TCR transgenic T cells up-regulate 4-1BB, OX40, and CD27 and respond to 4-1BBL-mediated costimulation during a primary response to peptide Ag. 4-1BBL enhanced proliferation, cytokine production, and CTL effector function of TCR transgenic T cells. To compare CD4 vs CD8 responses to 4-1BBL under similar conditions of antigenic stimulation, we performed MLRs with purified CD4 or CD8 responders from CD28(+/+) and CD28(-/-) mice. We found that CD8 T cells produced IL-2 and IFN-gamma in a 4-1BBL-dependent manner, whereas under the same conditions the CD4 T cells produced IL-2 and IL-4. 4-1BBL promoted survival of CD4 and CD8 T cells, particularly at late stages of the MLR. CD4 and CD8 T cells both responded to anti-CD3 plus s4-1BBL with a similar cytokine profile as observed in the MLR. CD4 and CD8 T cells exhibited enhanced proliferation and earlier cell division when stimulated with anti-CD3 plus anti-CD28 compared with anti-CD3 plus 4-1BBL, and both subsets responded comparably to anti-CD3 plus 4-1BBL. These data support the idea that CD28 plays a primary role in initial T cell expansion, whereas 4-1BB/4-1BBL sustains both CD4 and CD8 T cell responses, as well as enhances cell division and T cell effector function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:04:22