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Titolo:
Differential roles of cytokine receptors in the development of epidermal gamma delta T cells
Autore:
Ye, SK; Maki, K; Lee, HC; Ito, A; Kawai, K; Suzuki, H; Mak, TW; Chien, YH; Honjo, T; Ikuta, K;
Indirizzi:
Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan Kyoto Univ Kyoto Japan 6068501 Med Chem, Sakyo Ku, Kyoto 6068501, Japan Niigata Univ, Sch Med, Dept Dermatol, Niigata 951, Japan Niigata Univ Niigata Japan 951 ch Med, Dept Dermatol, Niigata 951, Japan Nagoya Univ, Grad Sch Med, Dept Immunol, Nagoya, Aichi, Japan Nagoya UnivNagoya Aichi Japan h Med, Dept Immunol, Nagoya, Aichi, Japan Amgen Inst, Toronto, ON, Canada Amgen Inst Toronto ON CanadaAmgen Inst, Toronto, ON, Canada Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 iol & Immunol, Stanford, CA 94305 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 4, volume: 167, anno: 2001,
pagine: 1929 - 1934
SICI:
0022-1767(20010815)167:4<1929:DROCRI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIC STROMAL LYMPHOPOIETIN; NATURAL-KILLER-CELLS; INTERLEUKIN-7 RECEPTOR; DEFICIENT MICE; IL-7 RECEPTOR; BETA-CHAIN; LYMPHOCYTE DEVELOPMENT; GENE REARRANGEMENT; ALPHA-CHAIN; MUTANT MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ikuta, K Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501,Japan Kyoto Univ Kyoto Japan 6068501 , Sakyo Ku, Kyoto 6068501, Japan
Citazione:
S.K. Ye et al., "Differential roles of cytokine receptors in the development of epidermal gamma delta T cells", J IMMUNOL, 167(4), 2001, pp. 1929-1934

Abstract

IL-7 and IL-15 play important roles in gamma delta T cell development. These receptors transmit proliferation and/or survival signals in,gamma delta T cells. In addition, the IL-7R promotes recombination and transcription inthe TCR gamma locus. To clarify the role of the cytokine receptors in the development of epidermal gamma delta T cells, we introduced a V gamma3/V delta1 TCR transgene, derived from Thy-1(+) dendritic epidermal T cells (DETC), into IL-7R alpha -deficient mice, and we found that they partly rescued gamma delta T cells in the adult thymus but not in the spleen. Introductionof an additional Bcl-2 transgene had a minimal effect on gamma delta T cells in the adult thymus of these mice. In contrast to the adult thymus, the introduction of the V gamma3/V delta1 TCR transgene into IL-7R alpha (-/-) mice completely restored V gamma3(+) T cells in the fetal thymus and DETC in the adult skin. On the contrary, the same V gamma3/V delta1 TCR transgenefailed to rescue DETC in the skin of IL-2R beta -deficient mice, even withthe additional Bcl-2 transgene. These results suggest that the IL-2/IL-15R, rather than the IL-7R, plays an essential role in proliferation and survival of DETC in the fetal thymus and the skin. In contrast, the IL-7R is probably essential in the induction of V-J recombination of TCR gamma genes. Thus, this study proves that IL-7R and IL-2/IL-15R serve differential functions in epidermal gamma delta T cell development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:17:07