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Titolo:
Use of dynamically coated capillaries for the routine analysis of methamphetamine, amphetamine, MDA, MDMA, MDEA, and cocaine using capillary electrophoresis
Autore:
Lurie, IS; Bethea, MJ; McKibben, TD; Hays, PA; Pellegrini, P; Sahai, R; Garcia, AD; Weinberger, R;
Indirizzi:
US Drug Enforcement Adm, Special Testing & Res Lab, Chantilly, VA 20151 USA US Drug Enforcement Adm Chantilly VA USA 20151 b, Chantilly, VA 20151 USA UN, Int Drug Control Program, Vienna Int Ctr, A-1400 Vienna, Austria UN Vienna Austria A-1400 Program, Vienna Int Ctr, A-1400 Vienna, Austria EuTech Sci Serv Inc, Highland Pk, NJ USA EuTech Sci Serv Inc Highland Pk NJ USA Sci Serv Inc, Highland Pk, NJ USA US Drug Enforcement Adm, SE Reg Lab, Miami, FL USA US Drug Enforcement Adm Miami FL USA ment Adm, SE Reg Lab, Miami, FL USA CE Technol, Chappaqua, NY USA CE Technol Chappaqua NY USACE Technol, Chappaqua, NY USA
Titolo Testata:
JOURNAL OF FORENSIC SCIENCES
fascicolo: 5, volume: 46, anno: 2001,
pagine: 1025 - 1032
SICI:
0022-1198(200109)46:5<1025:UODCCF>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; FUSED-SILICA CAPILLARIES; ZONE ELECTROPHORESIS; DRUG SEIZURES; SEPARATION; QUANTITATION; PROTEINS;
Keywords:
forensic science; forensic drug analysis; capillary electrophoresis; dynamically coated capillaries; amphetamine; methamphetamine; MDA; MDMA; MDEA; cocaine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Lurie, IS US Drug Enforcement Adm, Special Testing & Res Lab, 3650 Concorde Pkwy,Suite 200, Chantilly, VA 20151 USA US Drug Enforcement Adm 3650 Concorde Pkwy,Suite 200 Chantilly VA USA 20151
Citazione:
I.S. Lurie et al., "Use of dynamically coated capillaries for the routine analysis of methamphetamine, amphetamine, MDA, MDMA, MDEA, and cocaine using capillary electrophoresis", J FOREN SCI, 46(5), 2001, pp. 1025-1032

Abstract

A rapid, accurate, precise, reproducible, economical, and environmentally gentle method using capillary electrophoresis (CE) is presented for the routine analysis of methamphetamine, amphetamine, MDA, MDMA, MDEA, and cocainein seized drugs. The methodology uses a 32 cm by 50 mum capillary (length to detector 23.5 cm) with a commercially available buffer kit and diode array UV detection. Dynamic coating of the capillary surface is accomplished by flushing with base for 1 min, a proprietary polycation for 1 min, and then a proprietary polyanion for 2 min. This approach provides a relatively high and stable electroosmotic flow (EOF), even at low pHs. The background electrolyte (BGE) contains 75 mM phosphate buffer (pH 2.5) with the same polyanion as above. Using this methodology, amphetamine, methamphetamine. MDA, MDMA, MDEA, andan internal standard (n-butylamphetamine) are baseline resolved in less than 5 min. The run-to-run migration time %RSDs and peak area %RSDs are typically < 0.3% and < 2.1%, respectively. The day-to-day and capillary-to-capillary migration time %RSDs are < 1.5% and < 2.1%, respectively. The %RSDs ofthe relative migration times compared with the internal standard on a day-to-day and capillary-to-capillary basis are < 0.2% and < 0.06%, respectively. The linear dynamic range using peak areas range from 0.003 to 0.10 mg/mL. The correlation coefficients are > 0.9998, with all calibration curves passing at or near the origin. Similar data are obtained for cocaine and its internal standard henyltoloxamine. None of the compounds usually encountered in illicit samples interfere with the target compound (e.g., methamphetamine and cocaine) or the internal standard. Quantitative results for synthetic mixtures and seized exhibits are in good agreement with actual values, and also with results obtained fromother techniques. The relatively high EOF for the dynamically coated capillary system allows for the screening of basic, acidic, and neutral adulterants in drug seizures; identification is facilitated by the use of automatedUV library searches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:36:04