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Titolo:
Measurement of bisphenol A levels in human urine
Autore:
Brock, JW; Yoshimura, Y; Barr, JR; Maggio, VL; Graiser, SR; Nakazawa, H; Needham, LL;
Indirizzi:
Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA 30341 USA Ctr Dis Control & Prevent Atlanta GA USA 30341 lth, Atlanta, GA 30341 USA
Titolo Testata:
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
fascicolo: 4, volume: 11, anno: 2001,
pagine: 323 - 328
SICI:
1053-4245(200107/08)11:4<323:MOBALI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAS-CHROMATOGRAPHY; CARBOXYLIC-ACIDS; SEALANTS;
Keywords:
biomonitoring; bisphenol A; GC/MS; human; pentafluorobenzyl bromide; solid-phase extraction; urine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Brock, JW Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, 4770 Buford Highway MS F-17, Atlanta, GA 30341 USA Ctr Dis Control & Prevent 4770 BufordHighway MS F-17 Atlanta GA USA 30341
Citazione:
J.W. Brock et al., "Measurement of bisphenol A levels in human urine", J EXP AN EN, 11(4), 2001, pp. 323-328

Abstract

We report a new approach for assessing human exposure to bisphenol A (BPA)by measuring BPA in urine after enzymatic deglucuronidation. This method involves addition of C-13(12)-labeled BPA, enzymatic deconjugation, solid-phase extraction, and derivatization with pentafluorobenzyl bromide. The product of the derivatization is separated by gas chromatography followed by mass spectrometric detection using negative chemical ionization and selected ion monitoring. Using this analysis method, urine samples fortified with both a constant level of labeled BPA and a range of unlabeled BPA levels (0.27-10.6 ng/ml) demonstrated constant percentage recovery. In addition, a range of urine sample volumes (0.25-10.0 ml) with constant amounts of added internal standard produced a linear response (r(2)=0.99). The method limit ofdetection was 0.12 ng/ml. This method was validated by duplicate analyses using gas chromatography coupled to a high-resolution mass spectrometer.

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Documento generato il 30/05/20 alle ore 13:40:23