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Titolo:
Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: A home-based nightcap evaluation during drug administration and withdrawal
Autore:
Silvestri, R; Pace-Schott, EF; Gersh, T; Stickgold, R; Salzman, C; Hobson, JA;
Indirizzi:
Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Dept Psychiat,Lab Neurophysiol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 t,Lab Neurophysiol, Boston, MA 02115 USA Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, Psychopharmacol Program, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 opharmacol Program, Boston, MA 02115 USA Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Neurol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Dept Neurol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 8, volume: 62, anno: 2001,
pagine: 642 - 652
SICI:
0160-6689(200108)62:8<642:EOFAPO>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; DEPRESSED-PATIENTS; REM-SLEEP; FLUOXETINE; OUTPATIENTS; ANTIDEPRESSANTS; POLYSOMNOGRAM; QUALITY; EEG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Pace-Schott, EF Harvard Univ, Sch Med, Massachusetts Mental Hlth Ctr, DeptPsychiat,Lab Neurophysiol, 74 Fenwood Rd, Boston, MA 02115 USA Harvard Univ 74 Fenwood Rd Boston MA USA 02115 A 02115 USA
Citazione:
R. Silvestri et al., "Effects of fluvoxamine and paroxetine on sleep structure in normal subjects: A home-based nightcap evaluation during drug administration and withdrawal", J CLIN PSY, 62(8), 2001, pp. 642-652

Abstract

Background: Acute and chronic administration of the selective serotonin reuptake inhibitors (SSRIs) have been widely reported to disrupt sleep in laboratory studies. This study examines the naturalistic, longitudinal effectsof paroxetine and fluvoxamine on sleep quality in the home setting. Method: Fourteen healthy volunteers free of medical and neuropsychiatric symptoms entered a 31-day protocol: 7 days of drug-free baseline (days 1-7).19 days of drug treatment (steady state during days 18-26), and 5 days of acute withdrawal (days 27-31). On day 8, the subjects were randomly assigned to receive either 100 mg/day of fluvoxamine or 20 mg/day of paroxetine (half receiving each drug) in divided morning and evening oral doses. Investigators remained blinded to drug assignment until sleep data had been analyzed. Sleep was monitored using the Nightcap ambulatory sleep monitor. Four standard and 3 novel measures were computed and compared using multivariate analysis of variance, analysis of variance, and Bonferroni-corrected comparison of means. Results: Sleep disruption was most clearly important demonstrated using the novel measures eyelid quiescence index. rhythmicity, and eyelid movementsper minute in non-rapid eye movement sleep but was also apparent as determined by standard measures of sleep efficiency, number of awakenings, and sleep onset latency. Paroxetine disrupted sleep more than fluvoxamine, and, paroxetine- induced sleep disruption persisted into the withdrawal phase, Rapid eye movement sleep was suppressed during treatment (especially for fluvoxamine) and rebounded during withdrawal (especially for paroxetine). Conclusion: We confirm laboratory polysomnographic findings of SSRI-induced sleep quality changes and demonstrate the Nightcap's efficacy as an inexpensive longitudinal monitor for objective sleep changes induced by psychotropic medication.

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Documento generato il 18/01/20 alle ore 10:41:38