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Titolo:
Resistance to glucocorticoid feedback in obesity
Autore:
Jessop, DS; Dallman, MF; Fleming, D; Lightman, SL;
Indirizzi:
Univ Bristol, Univ Res Ctr Neuroendocrinol, Bristol BS2 8HW, Avon, EnglandUniv Bristol Bristol Avon England BS2 8HW Bristol BS2 8HW, Avon, England Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 9, volume: 86, anno: 2001,
pagine: 4109 - 4114
SICI:
0021-972X(200109)86:9<4109:RTGFIO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; BODY-FAT DISTRIBUTION; CORTICOTROPIN-RELEASING HORMONE; INSULIN-INDUCED HYPOGLYCEMIA; CORTISOL SECRETION; ABDOMINAL OBESITY; LEPTIN LEVELS; RAT-BRAIN; STRESS; DEXAMETHASONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Jessop, DS Univ Bristol, Bristol Royal Infirm, Univ Res Ctr Neuroendocrinol, Marlborough St, Bristol BS2 8HW, Avon, England Univ Bristol Marlborough St Bristol Avon England BS2 8HW ngland
Citazione:
D.S. Jessop et al., "Resistance to glucocorticoid feedback in obesity", J CLIN END, 86(9), 2001, pp. 4109-4114

Abstract

Increased hypothalamo-pituitary-adrenal axis drive has been reported in obese subjects but with paradoxically low or normal levels of plasma cortisol. Our current study was designed to investigate whether glucocorticoid feedback was altered in obesity, both under basal and stressed conditions. Plasma ACTH and cortisol concentrations in male control or obese subjects (age range 20-50 yr) were measured at frequent intervals over 24 h during infusion of saline or hydrocortisone at two physiological doses (7.5 and 15 mg/d)designed to occupy predominantly mineralocorticoid rather than glucocorticoid receptors. The same subjects then underwent insulin-induced hypoglycemia either in the morning or the evening. Obese subjects had significantly higher basal ACTH and lower cortisol concentrations throughout the 24 h infusion period, compared with controls (P < 0.05, two-way ANOVA followed by Newman-Keuls posthoc analysis). Basal plasma ACTH was decreased in obese groups given low- or high-dose hydrocortisone during the day (P < 0.05) but not during the night, unlike controls who responded to hydrocortisone both during the day and at night (P < 0.05). Obese subjects also showed resistance to steroid-induced inhibition of the ACTH response to hypoglycemia, comparedwith controls (P < 0.05). These data clearly show that obesity is associated with a relative insensitivity to glucocorticoid feedback, which is most marked during the night, and suggest that this condition is characterized by a decreased mineralocorticoid receptor response to circulating corticosteroids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 22:51:33