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Titolo:
Presence of neuronal nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal glands of the cat: an immunofluorescentand retrograde tracer double-labeling study
Autore:
Cheng, SB; Kuchiiwa, S; Kuchiiwa, T; Nonaka, S; Nakagawa, S;
Indirizzi:
Kagoshima Univ, Fac Med, Dept Anat, Kagoshima 8908520, Japan Kagoshima Univ Kagoshima Japan 8908520 pt Anat, Kagoshima 8908520, Japan Kagoshima Immaculate Heart Coll, Dept Life Sci, Kagoshima 890, Japan Kagoshima Immaculate Heart Coll Kagoshima Japan 890 Kagoshima 890, Japan Kagoshima Univ, Fac Med, Electron Microscopy Lab, Kagoshima 8908520, JapanKagoshima Univ Kagoshima Japan 8908520 opy Lab, Kagoshima 8908520, Japan
Titolo Testata:
JOURNAL OF CHEMICAL NEUROANATOMY
fascicolo: 3, volume: 22, anno: 2001,
pagine: 147 - 155
SICI:
0891-0618(200109)22:3<147:PONNOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR CERVICAL-GANGLION; MONKEY MACACA-FUSCATA; TOXIN-B-SUBUNIT; NADPH-DIAPHORASE; NERVE-FIBERS; GUINEA-PIG; POSTGANGLIONIC NEURONS; SYMPATHETIC NEURONS; CILIARY GANGLION; RAT;
Keywords:
nitric oxide; pterygopalatine ganglion; otic ganglion; trigeminal ganglion; superior vagal ganglion; superior glossopharyngeal ganglion; ciliary ganglion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Kuchiiwa, S Kagoshima Univ, Fac Med, Dept Anat, Sakuragaoka 8-35-1, Kagoshima 8908520,Japan Kagoshima Univ Sakuragaoka 8-35-1 Kagoshima Japan 8908520 pan
Citazione:
S.B. Cheng et al., "Presence of neuronal nitric oxide synthase in autonomic and sensory ganglion neurons innervating the lacrimal glands of the cat: an immunofluorescentand retrograde tracer double-labeling study", J CHEM NEUR, 22(3), 2001, pp. 147-155

Abstract

It is generally considered that parasympathetic postganglionic nerve fibers innervating the lacrimal gland (LG) arise from the pterygopalatine ganglion (PPG), while sympathetic and sensory innervations arise from the superior cervical ganglion (SCG) and trigeminal ganglion (TG), respectively. Recently, we reported for the first time that the parasympathetic innervation ofthe cat LG was also provided by the otic ganglion (OG) and ciliary ganglion (CG), and that the sensory innervation was also provided by the superior vagal ganglion (SVG) and superior glossopharyngeal ganglion (SGG). To determine if nitric oxide (NO) is a neurotransmitter of the autonomic and sensory neurons innervating the LG, we injected the cholera toxin B subunit (CTB)as a retrograde tracer into the cat LG, and used double-labeling fluorescent immunohistochemistry for CTB and nitric oxide synthase (NOS). We found that NOS-/CTB-immunofluorescent double-labeled perikarya were localized in the PPG, OG, TG, SVG and SGG, but not in the CG and SCG. The highest numbersof NOS-/CTB-immunofluorescent double-labeled neurons were found in the PPGand TG. In addition, we examined the presence of nitrergic nerve fibers inthe LG using NADPH-d histochemistry and found that a large amount of NADPH-d-stained nerve fibers were distributed around the glandular acini and in the walls of glandular ducts and blood vessels. This study provides the first direct evidence showing that NO may act as a neurotransmitter or modulator involved in the parasympathetic and sensory regulation of lacrimal secretion and blood circulation, but may not be implicated in the sympathetic control of LG activities, and that nitrergic nerve fibers in the LG arise mainly from parasympathetic postganglionic neurons in the PPG and sensory neurons in the TG. The present results suggest that NO plays an important role in the regulation of LG activities. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:29:22