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Titolo:
ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury
Autore:
Kobuke, K; Furukawa, Y; Sugai, M; Tanigaki, K; Ohashi, N; Matsumori, A; Sasayama, S; Honjo, T; Tashiro, K;
Indirizzi:
Kyoto Univ, Grad Sch Med, Ctr Mol Biol & Genet,Dept Med Chem, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 Med Chem, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 ovasc Med, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ, Grad Sch Med, Ctr Mol Biol & Genet, Sakyo Ku, Kyoto 6068507, Japan Kyoto Univ Kyoto Japan 6068507 l & Genet, Sakyo Ku, Kyoto 6068507, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 36, volume: 276, anno: 2001,
pagine: 34105 - 34114
SICI:
0021-9258(20010907)276:36<34105:EANNMP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ENDOTHELIAL GROWTH-FACTOR; DICTYOSTELIUM-DISCOIDEUM; CORONARY ANGIOPLASTY; GENETIC SELECTION; SEMAPHORIN-III; LIGAND-BINDING; ANGIOTENSIN-II; HIGH-AFFINITY; FACTOR-C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Tashiro, K Kyoto Univ, Grad Sch Med, Ctr Mol Biol & Genet,Dept Med Chem, Sakyo Ku, 53Kawahara Cho1, Kyoto 6068507, Japan Kyoto Univ 53 Kawahara Cho1 Kyoto Japan 6068507 6068507, Japan
Citazione:
K. Kobuke et al., "ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury", J BIOL CHEM, 276(36), 2001, pp. 34105-34114

Abstract

A novel cDNA has been isolated from primary culture of human coronary arterial cells by a signal sequence trap method, and designated ESDN ((e) underbar ndothelial and (s) under bar mooth muscle cell-(d) under bar erived (n) under bar europilin-like molecule). ESDN is a type-I transmembrane protein with the longest cleavable secretory signal sequence among eukaryotes. ESDN contains a CUB domain and a coagulation factor V/VIII homology domain, which reminds us of the structure of neuropilins. ESDN also harbors an LCCL domain, which is shared by Limulus factor C and Coch. Mouse and rat counterparts were also identified revealing > 84% amino acid identity with human ESDN. The human ESDN gene was mapped between D3S1552 and D3S1271. Northern blot analysis showed that ESDN mRNA was expressed in various tissues; particularly highly expressed in cultured vascular smooth muscle cells. The ESDN expression was up-regulated in platelet-derived growth factor-BB-stimulatedvascular smooth muscle cells in vitro and neointima of the balloon-injuredcarotid artery in vivo. Overexpression of ESDN in 293T cells suppressed their bromodeoxyuridine uptake. In addition, ESDN protein was strongly expressed in nerve bundles in rodents. Thus, ESDN is considered to play a role inregulation of vascular cell growth and may have a wide variety of functions in other tissues including the nervous system, like neuropilins.

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Documento generato il 06/04/20 alle ore 02:07:42