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Titolo:
Immunology and immunopathology of the male genital tract - Antisperm immunity in natural and assisted reproduction
Autore:
Lombardo, F; Gandini, L; Dondero, F; Lenzi, A;
Indirizzi:
Univ Roma La Sapienza, Dept Med Physiopathol, Unit Seminol & Immunol Reprod, I-00161 Rome, Italy Univ Roma La Sapienza Rome Italy I-00161 nol Reprod, I-00161 Rome, Italy
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 5, volume: 7, anno: 2001,
pagine: 450 - 456
SICI:
1355-4786(200109/10)7:5<450:IAIOTM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VITRO FERTILIZATION; INTRACYTOPLASMIC SPERM INJECTION; ANTI-SPERMATOZOAL ANTIBODIES; HUMAN INVITRO FERTILIZATION; PELLUCIDA TIGHT-BINDING; HUMAN FOLLICULAR-FLUID; HUMAN ZONA PELLUCIDA; CERVICAL-MUCUS; ACROSOME REACTION; INTRAPERITONEAL INSEMINATION;
Keywords:
antisperm antibodies; IVF; intracytoplasmic sperm injection; intrauterine insemination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Lombardo, F Univ Roma La Sapienza, Dept Med Physiopathol, Unit Seminol & Immunol Reprod, Piazzale Aldo Moro 5, I-00161 Rome, Italy Univ Roma La Sapienza Piazzale Aldo Moro 5 Rome Italy I-00161
Citazione:
F. Lombardo et al., "Immunology and immunopathology of the male genital tract - Antisperm immunity in natural and assisted reproduction", HUM REP UPD, 7(5), 2001, pp. 450-456

Abstract

Research conducted in the last 40 years has provided evidence that antisperm. antibodies (ASA) can impair the fertilizing capacity of human spermatozoa. It is established that ASA can be present at different sites, can act against different antigens and can impair fertility in various ways. In fact, in the past it was amply demonstrated that ASA can act negatively on sperm motility and on cervical mucus penetration. In recent years, owing to theimprovement and spreading of IVF techniques, it has been possible to demonstrate the effect of antibody-bound spermatozoa at the level of in-vitro gamete interaction. The literature demonstrates that the various previously used treatments for immunological infertility, i.e. medical therapy, intrauterine insemination with husband's spermatozoa (AIH) and IVF, usually had poor success. The primary choice of treatment in immunological infertility, especially in the most severe cases and when the sperm head is involved, is ICSI. ASA evaluation in all couples who undergo the various techniques of insemination or IVF is imperative.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:32:52