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Titolo:
Immunology and immunopathology of the male genital tract - Control and impairment of immune privilege in the testis and in semen
Autore:
Filippini, A; Riccioli, A; Padula, F; Lauretti, P; DAlessio, A; De Cesaris, P; Gandini, L; Lenzi, A; Ziparo, E;
Indirizzi:
Univ Roma La Sapienza, Dept Histol & Med Embryol, I-00161 Rome, Italy UnivRoma La Sapienza Rome Italy I-00161 ed Embryol, I-00161 Rome, Italy Univ Roma La Sapienza, Dept Med Pathophysiol, I-00161 Rome, Italy Univ Roma La Sapienza Rome Italy I-00161 thophysiol, I-00161 Rome, Italy Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy Univ Aquila Laquila Italy I-67100 Dept Expt Med, I-67100 Laquila, Italy
Titolo Testata:
HUMAN REPRODUCTION UPDATE
fascicolo: 5, volume: 7, anno: 2001,
pagine: 444 - 449
SICI:
1355-4786(200109/10)7:5<444:IAIOTM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN SEMINAL PLASMA; LIGAND-INDUCED APOPTOSIS; STIMULATORY FACTOR-II; HUMAN FAS LIGAND; SERTOLI CELLS; DOWN-REGULATION; T-LYMPHOCYTES; TNF-ALPHA; EXPRESSION;
Keywords:
cytokines; Fas; immune privilege; testis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Ziparo, E Univ Roma La Sapienza, Dept Histol & Med Embryol, Via A Scarpa 16, I-00161Rome, Italy Univ Roma La Sapienza Via A Scarpa 16 Rome Italy I-00161 Italy
Citazione:
A. Filippini et al., "Immunology and immunopathology of the male genital tract - Control and impairment of immune privilege in the testis and in semen", HUM REP UPD, 7(5), 2001, pp. 444-449

Abstract

It has long been known that the testis is an immunologically privileged site in the body, and that human seminal plasma possesses a generalized immunosuppressive activity. Multiple factors participate in the establishment ofimmunotolerance in the testis: the blood-tubular barrier; the local production of immunosuppressive molecules by Sertoli cells; and the Fas system asregulator of immunological homeostasis in both physiological and pathological conditions. Cytokine-induced up-regulation of Fas as well as of integrin ligands, which are known to be specific binding molecules for lymphocyteson the Sertoli cell surface, indicates that the 'nursing' cells of seminiferous epithelium might be important in the impairment of immune privilege, causing autoimmune orchitis. In addition, the soluble form of Fas-ligand protein present in the seminal plasma of infertile patients might suggest a role for this immunomodulatory protein in male infertility. Finally, an understanding of the mechanisms underlying immune privilege in the testis and in semen might help to clarify how cells expressing 'non-self' antigens (such as male gametes) can escape the immune system in both the male and femalegenital tracts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:35:20