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Titolo:
Contribution of sickle cell disease to the occurrence of developmental disabilities: A population-based study
Autore:
Ashley-Koch, A; Murphy, CC; Khoury, MJ; Boyle, CA;
Indirizzi:
Ctr Dis Control & Prevent, Off Genet & Dis Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA Environm Hlth, Atlanta, GA USA Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA & Dev Disabil, Atlanta, GA USA
Titolo Testata:
GENETICS IN MEDICINE
fascicolo: 3, volume: 3, anno: 2001,
pagine: 181 - 186
SICI:
1098-3600(200105/06)3:3<181:COSCDT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL DOPPLER; YOUNG-CHILDREN; STROKE; ANEMIA; RISK; ABNORMALITIES; TRANSFUSIONS; PREVENTION; COHORT;
Keywords:
sickle cell disease; developmental disabilities; stroke; epidemiology; surveillance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ashley-Koch, A Duke Univ, Med Ctr, Ctr Human Genet, 051 CARL Bldg, Durham,NC 27710 USA Duke Univ 051 CARL Bldg Durham NC USA 27710 m, NC 27710 USA
Citazione:
A. Ashley-Koch et al., "Contribution of sickle cell disease to the occurrence of developmental disabilities: A population-based study", GENET MED, 3(3), 2001, pp. 181-186

Abstract

Purpose: Population-based surveillance of children aged 3-10 years from metropolitan Atlanta was used to determine if stroke-related neurological damage in children with sickle cell disease (SCD) is associated with developmental disabilities (DD). Methods: School and medical records were reviewed annually to identify eligible children. Observed-to-expected ratios, P values, and population attributable fractions were calculated. Results: Childrenwith SCID had increased risk for DD (O/E = 3.2, P < 0.0001), particularly mental retardation (O/E = 2.7, P = 0.0005) and cerebral palsy (O/E = 10.8, P < 0.0001). This risk was confined to DD associated with stroke (O/E = 130, P < 0.0001; for DD without stroke: O/E = 1.3, P = 0.23). Conclusions: Children with SCD have increased risk for DID associated with stroke; thus, aggressive interventions are needed to prevent stroke in these children.

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Documento generato il 07/04/20 alle ore 04:10:16