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Titolo:
Dietary supplementation of N-3 fatty acids and hydroperoxide levels in ratretinas
Autore:
Wang, JY; Saito, M;
Indirizzi:
Natl Inst Hlth & Nutr, Div Food Sci, Shinjuku Ku, Tokyo 1628636, Japan Natl Inst Hlth & Nutr Tokyo Japan 1628636 njuku Ku, Tokyo 1628636, Japan
Titolo Testata:
FREE RADICAL RESEARCH
fascicolo: 4, volume: 35, anno: 2001,
pagine: 367 - 375
SICI:
1071-5762(2001)35:4<367:DSONFA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOCOSAHEXAENOIC ACID; GUINEA-PIG; MEMBRANE-COMPOSITION; LIGHT DAMAGE; HUMAN-PLASMA; LONG-CHAIN; BRAIN; PHOSPHOLIPIDS; INCREASES; LIPIDS;
Keywords:
rat retina; rod outer segment; fatty acid composition; DHA; peroxidation; hydroperoxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Wang, JY Natl Inst Hlth & Nutr, Div Food Sci, Shinjuku Ku, 1-23-1 Toyama, Tokyo 1628636, Japan Natl Inst Hlth & Nutr 1-23-1 Toyama Tokyo Japan 1628636 6, Japan
Citazione:
J.Y. Wang e M. Saito, "Dietary supplementation of N-3 fatty acids and hydroperoxide levels in ratretinas", FREE RAD RE, 35(4), 2001, pp. 367-375

Abstract

Docosahexaenoic acid (DHA) plays an important role in visual and neural development in mammals. In the present study, effect of dietary supplementation with n-3 fatty acids, primarily docosahexaenoic acid (DHA) with high purity, on the fatty acid composition of photoreceptor cells of young rats (fed from 4 weeks) was investigated. DHA in rod outer segment (ROS) membranes was significantly increased in the group of high DHA feeding (9.69% total energy). Other n-3 fatty acids (ce-linolenic acid (ALA) and eicosapentaenoicacid (EPA)) included in the diets with DHA (0.95% similar to 5.63% total energy) also significantly increased the proportion of DHA compared with thelinoleic acid diet groups. However, the proportions of arachidonic acid (ARA) and other long chain n-6 fatty acids (22:4n6 and 22:5n6) were suppressed in these n-3 fatty acids-fed groups. Phospholipid hydroperoxides in ROS membranes were determined using a highly sensitive analytical technique, chemiluminescence-high performance liquid chromatography (CL-HPLC). There was no increasing tendency in the hydroperoxide levels of ROS membranes containing high content of DHA, and phosphatidylethanolamine hydroperoxide (PEOOH)was much lower than phosphatidylcholine hydroperoxide (PCOOH) under normallight conditions, which implies that DHA supplementation does not much affect the peroxidizability of ROS membranes in vivo. But UV irradiation on separated ROS membranes accelerated the formation of phospholipid hydroperoxides in high DHA feeding rats, and PEOOH was produced more efficiently than PCOOH in vitro.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:32:44