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Titolo:
Assessment of long-term efficacy of hepatitis B vaccine
Autore:
Ayerbe, MC; Perez-Rivilla, A;
Indirizzi:
Dept Publ Hlth Serv, Gerencia Atenc Primaria Area Sanitaria 8, Madrid, Spain Dept Publ Hlth Serv Madrid Spain imaria Area Sanitaria 8, Madrid, Spain
Titolo Testata:
EUROPEAN JOURNAL OF EPIDEMIOLOGY
fascicolo: 2, volume: 17, anno: 2001,
pagine: 151 - 156
SICI:
0393-2990(2001)17:2<151:AOLEOH>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-HBS; BOOSTER VACCINATION; IMMUNE-RESPONSE; VIRUS-INFECTION; HOMOSEXUAL MEN; PROTECTION; IMMUNOGENICITY; CHILDREN; REVACCINATION; PERSISTENCE;
Keywords:
booster dose; hepatitis B vaccine; immunity duration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ayerbe, MC Alcalde Sainz de Baranda 20, Madrid 28009, Spain Alcalde Sainzde Baranda 20 Madrid Spain 28009 d 28009, Spain
Citazione:
M.C. Ayerbe e A. Perez-Rivilla, "Assessment of long-term efficacy of hepatitis B vaccine", EUR J EPID, 17(2), 2001, pp. 151-156

Abstract

In a healthy cohort of 462 subjects in which hepatitis B vaccine was administered between 1990 and 1992 a follow-up study was carried out to determine the duration of protection. Individuals with antibody against the hepatitis B virus surface antigen (anti-HBs) titer lower than 100 mIU/ml were administered a booster dose and antibodies determined 30 days later. The proportion of protection 6.5 years after vaccination was 85% (95% CI: 82-88). Only nine vaccinees seroconverted to anti-HBc positivity without becoming carrier or ill. In 125 subjects in which a booster dose was administered a significant increase in geometric mean of anti-HBs titer was observed (609 mIU/ml) as compared to late (13 mIU/ml) and early post-vaccination antibody levels (256 mIU/ml, Wilcoxon's test, p < 0.001) suggesting the existence of ananamnestic response. We conclude that in immunocompetent population it is not necessary to administer a booster dose 6.5 years after hepatitis B vaccination.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 11:12:11