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Titolo:
Drug-induced torsade de pointes: the perspectives of industry
Autore:
Carlsson, L;
Indirizzi:
AstraZeneca Res & Dev Molndal, Integrat Pharmacol, S-41383 Molndal, SwedenAstraZeneca Res & Dev Molndal Molndal Sweden S-41383 383 Molndal, Sweden
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: K, volume: 3, anno: 2001,
pagine: K114 - K120
SICI:
1520-765X(200109)3:K<K114:DTDPTP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
QT INTERVAL PROLONGATION; LEFT-VENTRICULAR DYSFUNCTION; CONGESTIVE-HEART-FAILURE; RABBIT PURKINJE-FIBERS; IN-VITRO; NONCARDIOVASCULAR DRUGS; COMBINED POTASSIUM; REPOLARIZATION; ASTEMIZOLE; TERODILINE;
Keywords:
drugs; action potential; repolarization; QT interval; torsade de pointes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Carlsson, L AstraZeneca Res & Dev Molndal, Integrat Pharmacol, S-41383 Molndal, Sweden AstraZeneca Res & Dev Molndal Molndal Sweden S-41383 Sweden
Citazione:
L. Carlsson, "Drug-induced torsade de pointes: the perspectives of industry", EUR H J SUP, 3(K), 2001, pp. K114-K120

Abstract

The appearance of QT prolongation and torsades de pointes during drug treatment is often unpredictable and has been recognised as a potential risk during treatment with antiarrhythmic as well as non-antiarrhythmic drugs. As a consequence, both regulatory bodies and the pharmaceutical industry are presently addressing the importance of early preclinical testing of novel compounds to identify QT prolongation and reassure safe clinical usage of newchemical entities. This paper briefly discusses some of the suggested in vitro methodologies and the predictive value of preclinical in vivo studies for assessment of repolarization delay of novel chemical entities. (Eur Heart J Supplements 2001; 3 (Suppl K): K114-K120) (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:32:26