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Titolo:
Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes
Autore:
Darpo, B;
Indirizzi:
Quintiles Serv, SE-11251 Stockholm, Sweden Quintiles Serv Stockholm Sweden SE-11251 erv, SE-11251 Stockholm, Sweden Karolinska Hosp, Dept Cardiol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 diol, S-10401 Stockholm, Sweden
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: K, volume: 3, anno: 2001,
pagine: K70 - K80
SICI:
1520-765X(200109)3:K<K70:SODPQI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECTIFIER POTASSIUM CURRENT; CHRONIC ATRIAL-FIBRILLATION; ARRHYTHMIA SUPPRESSION TRIAL; III ANTIARRHYTHMIC AGENT; DE-POINTES; VENTRICULAR-TACHYCARDIA; SINUS RHYTHM; CARDIAC-ARRHYTHMIA; INTRAVENOUS PROCAINAMIDE; CONVERSION EFFICACY;
Keywords:
torsades de pointes; QT prolongation; noncardiovascular drugs; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Darpo, B Quintiles Serv, Hornsbergsg 17, SE-11251 Stockholm, Sweden Quintiles Serv Hornsbergsg 17 Stockholm Sweden SE-11251 , Sweden
Citazione:
B. Darpo, "Spectrum of drugs prolonging QT interval and the incidence of torsades de pointes", EUR H J SUP, 3(K), 2001, pp. K70-K80

Abstract

The incidence of drug-induced proarrhythmias in the general population is largely unknown. Knowledge regarding incidence and risk factors is mainly derived from studies during clinical development of drugs and is therefore limited to antiarrhythmic compounds with a relatively high incidence. For non-cardiovascular drugs, proarrhythmias are rarely seen during clinical development but usually appear later, several years after registration. Both spontaneous adverse reaction reports and epidemiological studies have severe limitations when used to estimate the incidence of proarrhythmias with non-cardiovascular compounds. QT prolongation and torsades de pointes have beenassociated with non-sedating antihistamines, antibiotics, antipsychotics, antidepressants and a gastrointestinal prokinetic agent; drugs within theseclasses constitute the vast majority of non-cardiovascular compounds associated with this potentially serious side-effect. Epidemiological studies onnon-sedating antihistamines and on cisapride have largely failed to demonstrate an increased risk for sudden death or ventricular arrhythmias, which is most likely due to the low specificity of the end-points studied. A careful case ascertainment, which requires access to electrocardiograms and clinical records, and prospectively defined, strict definitions for the classification of proarrhythmias, is of great importance in these studies. (Eur Heart J Supplements 2001; 3 (Suppl K): K70-K80) (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:22:03