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Titolo:
Influence of gender on drug-acquired long QT syndrome
Autore:
Drici, MD;
Indirizzi:
Pasteur Univ Hosp, Dept Pharmacol, Nice, France Pasteur Univ Hosp Nice France r Univ Hosp, Dept Pharmacol, Nice, France CNRS, UPR 411, F-06560 Valbonne, France CNRS Valbonne France F-06560CNRS, UPR 411, F-06560 Valbonne, France
Titolo Testata:
EUROPEAN HEART JOURNAL SUPPLEMENTS
fascicolo: K, volume: 3, anno: 2001,
pagine: K41 - K47
SICI:
1520-765X(200109)3:K<K41:IOGODL>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TORSADE-DE-POINTES; HEART-RATE; VENTRICULAR REPOLARIZATION; CARDIAC-ARRHYTHMIAS; MOLECULAR-BASIS; SEX-DIFFERENCES; FEMALE GENDER; SMOOTH-MUSCLE; CYCLE LENGTH; RISK FACTOR;
Keywords:
gender difference; potassium channel blockers; long QT syndrome; I-Kr; ventricular arrhythmia; sudden death;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Drici, MD Fac Med Nice, Pharmacol Lab, Ave Valombrose, F-06107 Nice 02, France Fac Med Nice Ave Valombrose Nice France 02 6107 Nice 02, France
Citazione:
M.D. Drici, "Influence of gender on drug-acquired long QT syndrome", EUR H J SUP, 3(K), 2001, pp. K41-K47

Abstract

Numerous drugs from diverse classes, such as antiarrhythmics, antihistamines, gastrokinetics, antipsychotics and antibiotics, share the potential to induce a prolongation of the QT interval on the electrocardiogram and torsade de pointes ventricular arrhythmias. The underlying mechanism of these side-effects is the blocking of voltage-gated potassium channels, particularly the rapid component I-Kr, of the delayed rectifier I-K. The risk of such drug-induced arrhythmias is far greater in women than in men. Clinical dataas well as experimental studies show that, in comparison to men, the feminine gender is associated with a longer baseline QT interval, a greater response to drugs that block I-Kr and a greater propensity to drug-induced torsade de pointes. This is most likely the result of a specific regulation of channel expression by - and perhaps a direct non genomic effect of - sex steroids. (Eur Heart J Supplements 2001; 3 (Suppl K): K41-K47) (C) 2001 The European Society of Cardiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:58:13