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Titolo:
Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimers disease
Autore:
Moceri, VM; Kukull, WA; Emanual, I; van Belle, G; Starr, JR; Schellenberg, GD; McCormick, WC; Bowen, JD; Teri, L;
Indirizzi:
Univ Washington, Dept Epidemiol, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Community Med, Seattle, WA 98195 USA Univ Washington, Dept Environm Hlth & Biostat, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Community Med, Seattle, WA 98195 USA Univ Washington, Dept Maternal & Child Hlth Program, Sch Publ Hlth & Community Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Community Med, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pediat, Seattle, WA 98195 USA Univ Washington, Ctr Human Dev & Disabil, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dev & Disabil, Seattle, WA 98195 USA Univ Washington, Dept Med, Div Gerontol & Geriatr Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 & Geriatr Med, Seattle, WA 98195 USA Univ Washington, Dept Med, Div Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 d, Div Neurol, Seattle, WA 98195 USA Univ Washington, Dept Psychosocial & Community Hlth, Seattle, WA 98195 USAUniv Washington Seattle WA USA 98195 ommunity Hlth, Seattle, WA 98195 USA
Titolo Testata:
EPIDEMIOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 383 - 389
SICI:
1044-3983(200107)12:4<383:UCDABC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYLOID PRECURSOR PROTEIN; E ALLELE EPSILON-4; APOLIPOPROTEIN-E; COGNITIVE FUNCTION; SCHOOL-CHILDREN; MENARCHEAL AGE; SECRETED FORMS; SOCIAL-CLASS; RISK-FACTORS; HEIGHT;
Keywords:
early-life environment; census data; Alzheimer's disease; paternal occupation; gene-environment interaction; apolopoprotein epsilon 4 allele; socioeconomic status;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Moceri, VM Univ Washington, Dept Epidemiol, Sch Publ Hlth & Community Med,Box 357236, Seattle, WA 98195 USA Univ Washington Box 357236 Seattle WA USA 98195 e, WA 98195 USA
Citazione:
V.M. Moceri et al., "Using census data and birth certificates to reconstruct the early-life socioeconomic environment and the relation to the development of Alzheimers disease", EPIDEMIOLOG, 12(4), 2001, pp. 383-389

Abstract

The early-life environment and its effect on growth and maturation of children and adolescents are associated with several adult chronic diseases, including Alzheimer's disease. Because it is not feasible to collect information prospectively over the average life span, methods to reconstruct the early-life environment of the aged are necessary to evaluate these associations. In a community-based case-control study conducted in the United States,we collected U.S. census records and birth certificates to reconstruct theearly-life socioeconomic environment of each elderly subject. Information was found on 82% of the available Alzheimer's disease cases (239 of 292) and 87% of the available controls (245 of 282). We investigated risk of Alzheimer's disease associated with father's occupation, parental age, householdsize, sibship size, and birth order. Subjects whose fathers were unskilledmanual workers or laborers were at higher risk for Alzheimer's disease (odds ratio = 1.80, 95% confidence interval = 1.19-2.73). The risk of Alzheimer's disease was increased with increasing number of people in the household. We also evaluated whether subjects with the apolipoprotein epsilon4 allele (APOE epsilon4), a strong genetic risk factor that is not a necessary cause or a sufficient cause by itself for the development of Alzheimer's disease, were at higher risk than subjects who did not carry this allele. Among subjects with the APOE epsilon4 allele whose fathers held lower-socioeconomic level occupations, the odds of developing Alzheimer's disease were higher (odds ratio = 2.35, 95% confidence interval = 1.07-5.16) compared with subjects without the allele (odds ratio = 1.40, 95% confidence interval = 0.78-2.52). Subjects carrying the APOE epsilon4 allele alone have a threefold increased risk of Alzheimer's disease (odds ratio = 3.17, 95% confidence interval = 1.99-5.04). Compared with subjects with neither risk factor, subjects with both the genetic and the environmental risk factors (household size of seven or more and father's occupation being manual) had a relatively high risk of Alzheimer's disease (odds ratio = 14.8, 95% confidence interval= 4.9-46). The data suggest that APOE epsilon4 may modify the associationsbetween father's occupation, other early-life environmental factors, and development of Alzheimer's disease in late life.

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Documento generato il 28/01/20 alle ore 21:00:40