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Titolo:
From proteomics to genomics
Autore:
Sperling, K;
Indirizzi:
Inst Humangenet Charite, D-13353 Berlin, Germany Inst Humangenet Charite Berlin Germany D-13353 , D-13353 Berlin, Germany
Titolo Testata:
ELECTROPHORESIS
fascicolo: 14, volume: 22, anno: 2001,
pagine: 2835 - 2837
SICI:
0173-0835(200108)22:14<2835:FPTG>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED POINT MUTATIONS; 2-DIMENSIONAL ELECTROPHORESIS; MASS-SPECTROMETRY; PROTEINS; MOUSE; IDENTIFICATION; BRAIN;
Keywords:
proteomics; genomics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sperling, K Inst Humangenet Charite, Augustenburger Pl 1, D-13353 Berlin, Germany Inst Humangenet Charite Augustenburger Pl 1 Berlin Germany D-13353
Citazione:
K. Sperling, "From proteomics to genomics", ELECTROPHOR, 22(14), 2001, pp. 2835-2837

Abstract

Presently, science is moving from genomics to proteomics in order to get insight into the functional network of gene expression. Actually however, proteomics is much older than genomics and dates back to the introduction of the two-dimensional gel electrophoresis technique (2-DE) independently by Klose and O'Farrell. Based on this approach almost all cellular proteins canbe separated. New developments in mass spectrometry allowed identificationof single spots in the 2-DE protein pattern, including the underlying genes. Joachim Klose has focused his pioneering 2-DE studies on mouse models with special emphasis on quantitative protein variants. According to him, proteins are living molecules exhibiting a characteristic protein phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 00:38:31