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Titolo:
Allele-specific X-linked gene activity in normal human cells assayed by expressed single nucleotide polymorphisms (cSNPs)
Autore:
Vasques, LR; Pereira, LV;
Indirizzi:
Univ Sao Paulo, Inst Biociencias, Dept Biol, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil ociencias, Dept Biol, Sao Paulo, Brazil
Titolo Testata:
DNA RESEARCH
fascicolo: 4, volume: 8, anno: 2001,
pagine: 173 - 177
SICI:
1340-2838(20010831)8:4<173:AXGAIN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMOSOME INACTIVATION; ASSEMBLY PROGRAM;
Keywords:
single nucleotide polymorphisms (SNP); expressed polymorphisms; dosage compensation; X chromosome inactivation; imprinting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Pereira, LV Rua Matao 277-350, BR-05508900 Sao Paulo, Brazil Rua Matao 277-350 Sao Paulo Brazil BR-05508900 BCulo, Brazil
Citazione:
L.R. Vasques e L.V. Pereira, "Allele-specific X-linked gene activity in normal human cells assayed by expressed single nucleotide polymorphisms (cSNPs)", DNA RES, 8(4), 2001, pp. 173-177

Abstract

In mammals, dosage compensation at X-linked loci is achieved by the process of X chromosome inactivation in the homogametic sex. While most genes on the inactive X chromosome (Xi) are subjected to transcriptional inactivation, some escape inactivation and present biallelic expression. The expression status of X-linked genes has been extensively studied in somatic cell hybrids containing only the human Xi. Although this approach has recently beenused to generate a profile of X-linked gene activity, it may not reflect what happens in a normal human cell. The recent development of a database ofsingle nucleotide polymorphisms (SNPs) throughout the human genome enablesinvestigation of allele-specific gene expression in normal human cells. Inthis study, we established a panel of X-linked expressed SNPs (cSNPs). These markers were used for monitoring gene expression in primary human fibroblast cell lines with completely skewed XCI, demonstrating the potential of this system for studying X-linked gene expression in normal human cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 10:56:59