Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Measles is more prevalent in Crohn's disease patients. A multicentre Israeli study
Autore:
Lavy, A; Broide, E; Reif, S; Keter, D; Niv, Y; Odes, S; Eliakim, R; Halak, A; Ron, Y; Patz, J; Fich, A; Villa, Y; Arber, N; Gilat, T;
Indirizzi:
Asaf Ctr, Dept Gastroenterol, Tel Aviv, Israel Asaf Ctr Tel Aviv IsraelAsaf Ctr, Dept Gastroenterol, Tel Aviv, Israel Tel Aviv Univ, Dept Gastroenterol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 nterol, IL-69978 Tel Aviv, Israel
Titolo Testata:
DIGESTIVE AND LIVER DISEASE
fascicolo: 6, volume: 33, anno: 2001,
pagine: 472 - 476
SICI:
1590-8658(200108/09)33:6<472:MIMPIC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY-BOWEL-DISEASE; POLYMERASE-CHAIN-REACTION; IMMUNOGOLD ELECTRON-MICROSCOPY; VIRUS INFECTION; RISK-FACTORS;
Keywords:
inflammatory bowel disease; measles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lavy, A Bnai Zion Med Ctr, Golomb Str, Haifa, Israel Bnai Zion Med Ctr Golomb Str Haifa Israel omb Str, Haifa, Israel
Citazione:
A. Lavy et al., "Measles is more prevalent in Crohn's disease patients. A multicentre Israeli study", DIG LIVER D, 33(6), 2001, pp. 472-476

Abstract

The question whether there is a transmissible pathogenetic agent as a cause for Crohns disease, remains unanswered. Measles virus has been the subject of many intensive studies, in the attempt to find a role for it in the pathogenesis of inflammatory bowel disease. Whether an early infection with measles virus may predispose to Crohn's disease in later life is still not clear. We conducted a large scale multicentre study, in order to obtain sufficient data to answer this question. To do so, we compared inflammatory bowel disease patients, with Crohns disease or ulcerative colitis, with two matched control groups: clinical controls, and community controls. A total of531 patients, 271 with ulcerative colitis and 260 with Crohns disease wereinterviewed, as well as 903 matched controls. Blood from 104 inflammatory bowel disease patients and 50 controls was tested for antibodies to measlesvirus. We did not find any differences related to measles vaccination, either in Crohns disease or in ulcerative colitis. Exposure to measles in childhood was more frequent in Crohns disease patients than in their controls, the difference being statistically significant [p<0.05) in relation to community controls. The presence of IgG antibodies to measles virus was higher in patients with Crohn's disease than in patients with ulcerative colitis or controls (p=0.084). Another observation of interest was the finding that Crohn's disease patients who had measles in childhood, more frequently had large bowel disease than those who had not had measles. These data lead us to postulate that there may be a role for measles infection in Crohn's disease, even if, at present, this role remains unclear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/02/20 alle ore 15:03:52