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Titolo:
Acute bleeding complications in patients after bone marrow transplantation
Autore:
Nevo, S; Vogelsang, GB;
Indirizzi:
Dept Oncol, Baltimore, MD USA Dept Oncol Baltimore MD USADept Oncol, Baltimore, MD USA
Titolo Testata:
CURRENT OPINION IN HEMATOLOGY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 319 - 325
SICI:
1065-6251(200109)8:5<319:ABCIPA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROPHYLACTIC PLATELET TRANSFUSION; DIFFUSE ALVEOLAR HEMORRHAGE; HIGH-DOSE CHEMOTHERAPY; STEM-CELL TRANSPLANTATION; CONTINUOUS BLADDER IRRIGATION; ACUTE MYELOID-LEUKEMIA; V-HOST DISEASE; RISK-FACTORS; NEUROLOGIC COMPLICATIONS; PULMONARY COMPLICATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Nevo, S Bunting Blaustein Bldg Canc Res,1650 Orleans St, Baltimore, MD 21231 USA Bunting Blaustein Bldg Canc Res,1650 Orleans St Baltimore MD USA 21231
Citazione:
S. Nevo e G.B. Vogelsang, "Acute bleeding complications in patients after bone marrow transplantation", CURR OPIN H, 8(5), 2001, pp. 319-325

Abstract

Acute bleeding is a frequent complication that commonly associates with increased morbidity after bone marrow transplantation. Except for diffuse alveolar hemorrhage and cerebral hemorrhage, bleeding is infrequently recordedas a direct cause of death. Yet outcome analyses showed that bleeding fromany reviewed site was associated with reduced survival. Reduced survival was correlated with bleeding intensity and the number of bleeding sites. These data point to the need to monitor all manifestations of bleeding, as bleeding may identify patients at risk for bone marrow transplantation toxicity. Until recently, prophylactic platelet transfusions were commonly given at a trigger of 20 X 10(9)/L. Whereas bleeding is more likely to occur when platelet counts drop to low levels, most bleeding episodes were recorded with platelet counts greater than 20 X 10(9)/L, suggesting causes other than profound thrombocytopenia in the pathogenesis of bleeding. Given that a trigger of 10 X 10(9)/L has become accepted for prophylactic platelet transfusions, care should be taken to ensure that parameters other than the incidence of bleeding have not been adversely affected. Curr Opin Hematol 2001, 8:319-325 (C) 2001 Lippincott Williams & Wilkins, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 21:34:52