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Titolo:
Effects of RU 486 on electrical activity, on sexual steroid and prostaglandin F-2 alpha concentrations in the myometrium at mid-pregnancy in the rat
Autore:
Bouftila, B; Clabaut, M;
Indirizzi:
Univ Rouen, Lab Physiopathol Foetomaternelle, Fac Sci & Tech, F-76821 MontSt Aignan, France Univ Rouen Mont St Aignan France F-76821 , F-76821 MontSt Aignan, France
Titolo Testata:
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES
fascicolo: 9, volume: 324, anno: 2001,
pagine: 805 - 813
SICI:
0764-4469(200109)324:9<805:EOR4OE>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGESTERONE; ANTIPROGESTERONE; RECEPTOR; RU-486; RU486; ACTIVATION; PROTEINS; ESTROGEN; OXYTOCIN; UTERUS;
Keywords:
RU 486; uterine contraction; sexual steroids; PGF(2 alpha);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Bouftila, B Univ Rouen, Lab Physiopathol Foetomaternelle, Fac Sci & Tech, BP 118, F-76821 Mont St Aignan, France Univ Rouen BP 118 Mont St Aignan France F-76821 ignan, France
Citazione:
B. Bouftila e M. Clabaut, "Effects of RU 486 on electrical activity, on sexual steroid and prostaglandin F-2 alpha concentrations in the myometrium at mid-pregnancy in the rat", CR AC S III, 324(9), 2001, pp. 805-813

Abstract

Effects of RU 486 (10 mg(.)kg(-1), per.os) were assessed at mid-pregnancy in the rat. One hour after RU 486 treatment, myometrial electrical activitystayed low. It increased from the 3rd hour after administration of RU 486 and a perfect synchronization of the bursts of the action potentials was observed from the 6th h to the 24th h. Tissular steroid hormones and PGF(2 alpha) evaluated at hour 6 after RU 486 administration, showed a decrease of progesterone concentrations in both myometrium and uterus. Estradiol levelsdecreased in uterus whereas, PGF(2 alpha) levels increased in both myometrium and uterus. These results show for the first time that RU 486 strongly increases the myometrial electrical activity in the rat at mid-pregnancy. This action was closely related to E-2, P-4 and PGF(2 alpha) concentrations. (C) 2001 Academie des sciences/Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:20:18