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Titolo:
Effects of haloperidol and phentolamine on the crustacean cardiac ganglion
Autore:
Berlind, A;
Indirizzi:
Wesleyan Univ, Dept Biol, Middletown, CT 06457 USA Wesleyan Univ Middletown CT USA 06457 Dept Biol, Middletown, CT 06457 USA
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 130, anno: 2001,
pagine: 85 - 95
SICI:
1532-0456(200109)130:1<85:EOHAPO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE ADENYLATE-CYCLASE; LOBSTER HOMARUS-AMERICANUS; LOCUST NERVOUS-TISSUE; ANTIPSYCHOTIC-DRUGS; DOPAMINE-RECEPTOR; APIS-MELLIFERA; NEURONS; OCTOPAMINE; CLOZAPINE; CRAB;
Keywords:
lobster; cardiac ganglion; monoamine; haloperidol; phentolamine; driver potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Berlind, A Wesleyan Univ, Dept Biol, Middletown, CT 06457 USA Wesleyan Univ Middletown CT USA 06457 Middletown, CT 06457 USA
Citazione:
A. Berlind, "Effects of haloperidol and phentolamine on the crustacean cardiac ganglion", COMP BIOC C, 130(1), 2001, pp. 85-95

Abstract

Haloperidol (a dopamine D-2 blocker in vertebrates) and phentolamine (an a-adrenergic blocker) alter the pattern of bursting by the isolated cardiac ganglion of the lobster when perfused at concentrations of 10(-6)-10(-5) mol/l. Both drugs decrease the frequency of bursting and increase burst duration. They are most effective in slowing the ganglion when applied selectively to the anterior ganglionic trunk, the same region of the ganglion where dopamine (DA) and 5-hydroxytryptamine (5HT) are most effective in speeding up bursting. When exogenous monoamine transmitters are applied in the presence of 3 X 10(-6) mol/l haloperidol, the effect of 5HT, but not of DA, is significantly reduced. At the same concentration, phentolamine does not suppress the actions of DA, 5HT or noradrenaline (NA). Both haloperidol and phentolamine significantly alter the properties of endogenous burst-organizingpotentials (driver potentials) generated by motorneurons in the ganglion. It is possible that the effects of these drugs on bursting reflect alteration of endogenous electrical properties of the constituent neurons, rather than receptor antagonism. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:44:09