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Titolo:
Cadmium-induced abnormality in strains of Euglena gracilis: morphological alteration and its prevention by zinc and cyanocobalamin
Autore:
Watanabe, M; Suzuki, T;
Indirizzi:
Hokkaido Univ, Grad Sch Fisheries Sci, Div Marine Life Sci, Hakodate, Hokkaido 0418611, Japan Hokkaido Univ Hakodate Hokkaido Japan 0418611 te, Hokkaido 0418611, Japan
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 1, volume: 130, anno: 2001,
pagine: 29 - 39
SICI:
1532-0456(200109)130:1<29:CAISOE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAVY-CHAIN GENE; RESISTANCE; CELLS;
Keywords:
abnormal cell proliferation; cadmium; cyanocobalamin; cytotoxicity; cytokinesis; Euglena gracilis; hypertrophy; zinc;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Watanabe, M Hokkaido Univ, Grad Sch Fisheries Sci, Div Marine Life Sci, Hakodate, Hokkaido 0418611, Japan Hokkaido Univ Hakodate Hokkaido Japan 0418611 0418611, Japan
Citazione:
M. Watanabe e T. Suzuki, "Cadmium-induced abnormality in strains of Euglena gracilis: morphological alteration and its prevention by zinc and cyanocobalamin", COMP BIOC C, 130(1), 2001, pp. 29-39

Abstract

Euglena gracilis is susceptible to cadmium (Cd) at high concentrations. There are no comparative data on cytotoxicity or abnormality of CdCl2 to E. gracilis Z and its achlorophyllous mutant SMZ. The present study examined the cytotoxicity of CdCl2 under continual exposure at levels ranging from sub-ppm to ppm, and assessed the effects of zinc (Zn) or cyanocobalamin (VB,,)supplementation on the suppression of Cd-induced abnormal cell proliferation and hypertrophy. With Zn levels restricted to I ppm [as Zn++], cell growth of both E. gracilis strains was reduced in proportion to Cd concentration. More abnormal cells (hypertrophied, V-shape and starfish-shape) were observed in both strains at sub-ppm levels of Cd. ZnSO4 supplementation from 2to 63 ppm significantly suppressed the incidence of Cd-induced abnormality. However, a significant increase in abnormal cells was observed following Zn supplementation at levels of 125 and 250 ppm, which produced remarkable differences in cell morphology. The incidence of abnormal cells varied withsupplemented VB12 levels ranging from 4 to 250 ppb in both E. gracilis strains. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:47:46